Antigen Presentation Keeps Trending in Immunotherapy Resistance.

Antigen Presentation Keeps Trending in Immunotherapy Resistance.
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DOI:
10.1158/1078-0432.ccr-18-0698
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发表时间:
2018-07-15
期刊:
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子:
--
通讯作者:
Ribas A
Ribas A
中科院分区:
其他
文献类型:
--
作者:
Kalbasi A;Ribas A

文献摘要

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通过功能获得性激酶组筛选,MEX 3B被鉴定为先前使用基于CRISPR的筛选未鉴定出的对T细胞免疫疗法的抗性的介体。MEX 3B是HLA-A的转录后调节因子,验证了肿瘤内在抗原呈递在T细胞免疫治疗中的关键作用,并指示了新的推定分子靶点。
Through a gain-of-function kinome screen, MEX3B was identified as a mediator of resistance to T cell immunotherapy not previously identified using CRISPR based screens. MEX3B is a post-transcriptional regulator of HLA-A, validating the critical role of tumor-intrinsic antigen presentation in T cell immunotherapy and indicating a new putative molecular target.