Antigen Presentation Keeps Trending in Immunotherapy Resistance.
Antigen Presentation Keeps Trending in Immunotherapy Resistance.
复制标题
DOI:
10.1158/1078-0432.ccr-18-0698
复制
发表时间:
2018-07-15
期刊:
影响因子:
--
通讯作者:
Ribas A
中科院分区:
文献类型:
--
作者:
Kalbasi A;Ribas A
Through a gain-of-function kinome screen, MEX3B was identified as a mediator of resistance to T cell immunotherapy not previously identified using CRISPR based screens. MEX3B is a post-transcriptional regulator of HLA-A, validating the critical role of tumor-intrinsic antigen presentation in T cell immunotherapy and indicating a new putative molecular target.