The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark
The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark
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DOI：
10.1211/0022357001777432
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发表时间：
2000-11-01
影响因子：
3.3
通讯作者：
Maruyama, Y
中科院分区：
文献类型：
--
作者：
Kuribara, H;Kishi, E;Maruyama, Y
一项改进的小鼠高架十字迷宫试验显示，每天用两种不同的中药（在日本被称为汉方药，Hange-koboku-to（由5种植物的提取物组成）和Saiboku-to（由10种植物的提取物组成））治疗7次，产生了抗焦虑作用，这种作用主要是由于存在来自日本的和厚朴。本研究旨在评价和厚朴、Hange-koboku-to和Saiboku-to的抗焦虑潜力，这两种药物分别与两种不同的厚朴样品：Kara-koboku（Magnoliae officinalis）（KA）或Wa-koboku（Magnoline obovata）（WA）一起处方。调整试验样品的剂量，以确保和厚朴的剂量恒定在0.2 mg kg（-1）。虽然厚朴酚（和厚朴酚的异构体）以及未确定的化学物质的剂量在样品之间存在差异，但10个试验样品中有9个每天7次处理产生的抗焦虑作用几乎相当于0.2 mg kg（-1）和厚朴酚产生的作用。唯一的例外是含有最低量的和厚朴酚的样品。不含木兰的半叶厚朴汤或西木汤制剂没有任何抗焦虑作用。这些结果证实了从蒲公英中提取的和厚朴酚是半叶厚朴汤和西木汤抗焦虑作用的原因化学物质。
An improved elevated plus-maze test in mice revealed that seven daily treatments with two different traditional Chinese medicines, known as Kampo medicines in Japan, Hange-koboku-to (composed of extracts of 5 plants) and Saiboku-to (composed of extracts of 10 plants), produced an anxiolytic effect, and the effect was mainly due to the presence of honokiol derived from magnolia. This study was carried out to evaluate the anxiolytic potential of honokiol, Hange-koboku-to and Saiboku-to, which were prescribed with two different magnolia samples: Kara-koboku (Magnoliae officinalis) (KA) or Wa-koboku (Magnoline obovata) (WA).The doses of test samples were adjusted to ensure a constant dose of honokiol at 0.2 mg kg(-1). Although the doses of magnolol (an isomer of honokiol), as well as those of undetermined chemicals, varied among samples, the seven daily treatments with 9 out of 10 test samples produced an anxiolytic effect almost equivalent to that produced by 0.2 mg kg(-1) honokiol. The only exception was the sample containing the lowest amount of honokiol. Magnolia-free preparations of Hange-koboku-to or Saiboku-to did not have any anxiolytic effect.These results confirm that honokiol derived from magnolia is the causal chemical of the anxiolytic effect of Hange-koboku-to and Saiboku-to.