Effects of ethanol: II. Behavioral sensitivity and acute behavioral tolerance.
Effects of ethanol: II. Behavioral sensitivity and acute behavioral tolerance.
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乙醇的作用：II。
DOI：
10.1111/j.1530-0277.1984.tb05682.x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Cole,RE
中科院分区：
文献类型：
--
作者：
Wilson,JR;Erwin,VG;McClearn,GE;Plomin,R;Johnson,RC;Ahern,FM;Cole,RE
48名年轻男性受试者（24对兄弟）服用两剂乙醇，5对兄弟（对照组）服用安慰剂。计算剂量1使血液酒精含量（BAC）峰值为100 mg/100 ml；当BAC下降到剂量1产生的峰值BAC的一半时，给予剂量2，试图将BAC提高到100 mg/100 ml。在酒精剂量之前，对许多行为测试进行了基础hne测量。将剂量1和剂量2代谢期间的行为表现与基线表现进行比较。对乙醇的敏感性表现为几乎所有的性能下降。添加乙醇后的试验。在某些试验中，与BACs大致相等的剂量1后的表现相比，剂量2后的表现有所改善，表明对乙醇的急性行为耐受（ABTE）。通过比较兄弟俩的得分，初步寻找敏感性和ABTE可能的遗传成分。对乙醇的敏感性，通过平均性能下降来测量，在本研究中采用的许多测试中都发现，在运动任务中看到更大的下降。尽管总体上平均表现下降，但在表现上存在显著的个体差异，少数个体在乙醇剂量后表现更好。平均得分显示，在清除第二剂量乙醇期间，表现有一致的改善趋势。我们把这种现象称为“对乙醇的急性行为耐受”。当简短的个别测试被汇总成一个“电机”测试组和一个“书面”测试组时，ABTE显然是一个显著的影响。尽管亲疏性测试（通过兄弟相似度）并不确定，也许是由于样本量小，但揭示了对乙醇反应亲疏性的进一步研究的一些有希望的线索。
Two doses of ethyl alcohol were administered to 48 young male subjects (24 brother‐pairs), and placebo doses were administered, to five brother‐pairs (controls). Dose 1 amount was calculated to result in a peak blood alcohol content (BAC) of 100 mg/100 ml; dose 2 was given when BAC had fallen to one‐half the peak BAC resulting from dose 1, in an attempt to raise BAC back to 100 mg/100 ml. Prior to alcohol dosage, baseHne measurements were made on a number of behavioral tests. Behavioral performances during metabolism of doses 1 and 2 were compared to baseline performance. Sensitivity to ethanol was indicated by performance decrements on nearly all. tests after ethanol dosing. Acute behavioral tolerance to ethanol (ABTE) was indicated for some tests by improved performance after dose 2 compared to performance at a time after dose 1 when BACs were about equivalent A preliminary search for possible genetic components of sensitivity and ABTE was undertaken by comparing the scores of the brothers.SUMMARY1. Sensitivity to ethanol, measured via a mean performance decrement, was found for many of the tests employed in this study, with larger decrements seen on motor tasks.2. Despite the overall picture of average performance decrements, there was striking individual variability in performance, and a few individuals performed better after ethanol dosage.3. Mean scores revealed a consistent trend for improved performance during clearance of the second dose of ethanol. We have termed this phenomenon “acute behavioral tolerance to ethanol.” When the short individual tests were summed to form a “motor” test battery and a “written” test battery, ABTE was clearly a significant effect.4. Even though tests of familiality (via resemblance of brothers) were not definitive, perhaps due to the small sample size, several promising leads for further research on familiality of responses to ethanol were revealed.