Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages.
Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages.
复制标题
大鼠表面活性蛋白 D 增强大鼠肺泡巨噬细胞产生氧自由基。
作者：
J. F. V. Iwaarden;T. Hiroshi;Shimizu;P. H. M. V. Golde;Dennis R. VOELKERt;L. V. Golde
大鼠肺表面活性蛋白D（SP-D）可增强大鼠肺泡巨噬细胞产生氧自由基。这种增强，这是由光泽精依赖性化学发光测定，是最大的18分钟后，在0.2微克/毫升的SP-D浓度。表面活性剂脂质不影响刺激肺泡巨噬细胞的SP-D，而这些细胞诱导的表面活性剂蛋白A的氧自由基的产生被抑制的脂质浓度依赖性的方式。
Rat surfactant protein D (SP-D) was shown to enhance the production of oxygen radicals by rat alveolar macrophages. This enhancement, which was determined by a lucigenin-dependent chemiluminescence assay, was maximal after 18 min at an SP-D concentration of 0.2 micrograms/ml. Surfactant lipids did not influence the stimulation of alveolar macrophages by SP-D, whereas the oxygen-radical production of these cells induced by surfactant protein A was inhibited by the lipids in a concentration-dependent manner.