Increase of IgA-bearing peripheral blood lymphocytes in families of patients with IgA nephropathy.
Increase of IgA-bearing peripheral blood lymphocytes in families of patients with IgA nephropathy.
复制标题
IgA肾病患者家族中携带IgA的外周血淋巴细胞增加。
DOI：
10.1093/ajcp/72.3.452
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发表时间：
1979
影响因子：
3.5
通讯作者：
K. Tsuji
中科院分区：
文献类型：
--
作者：
H. Sakai;Y. Nomoto;S. Arimori;K. Komori;H. Inouye;K. Tsuji
通过对伊加肾病患者及其家系成员外周血IgA淋巴细胞、血清伊加、尿沉渣及HLA分型的检测，探讨伊加肾病的发生与家族因素的关系。对10例伊加肾病患者、31例家族成员和36例年龄匹配的健康人进行了检测。所有的家庭包括某些成员的IgA轴承外周血淋巴细胞的数量增加。IgA携带淋巴细胞增加的家庭成员的出现模式是垂直的。一些IgA携带淋巴细胞增加的家庭成员在研究时表现出微量血尿。外周血淋巴细胞IgA含量与血清伊加水平无明显相关性。10例患者的HLA分型与一般人群无明显差异。提示检测家族成员外周血IgA阳性淋巴细胞有助于伊加肾病的筛查。
IgA-bearing peripheral blood lymphocytes, serum IgA, urinary sediments and HLA types of patients with IgA nephropathy and members of their families were examined to elucidate whether some familial factors might be related to the development of IgA nephropathy. Ten patients with IgA nephropathy, 31 family members and 36 age-matched healthy persons were examined. All families included certain members with increased amounts of IgA-bearing peripheral blood lymphocytes. The pattern of the emergence of family members with increased IgA-bearing lymphocytes was vertical. Some family members who had increased IgA-bearing lymphocytes showed microhematuria at the time of the study. There was no significant correlation between the amounts of IgA-bearing peripheral blood lymphocytes and levels of serum IgA. HLA types of the ten patients did not show significant deviation from those in the general population. It is suggested that the measurement of IgA-bearing peripheral blood lymphocytes among family members is useful for the screening of patients with IgA nephropathy.