Utility of preclinical drug versus food choice procedures to evaluate candidate medications for methamphetamine use disorder.
Utility of preclinical drug versus food choice procedures to evaluate candidate medications for methamphetamine use disorder.
复制标题
DOI：
10.1111/nyas.13276
复制
发表时间：
2017-04
影响因子：
5.2
通讯作者：
Banks ML
中科院分区：
文献类型：
--
作者：
Banks ML
物质使用障碍被诊断为对滥用药物的不适当行为分配的表现，并且远离由更具适应性的非药物滥用者维持的其他行为（例如，工作和社会关系）。物质使用障碍的治疗目标不仅包括减少药物维持行为，还包括促进行为向这些社会适应性替代药物的重新分配。临床前药物自我给药程序同时提供药物和非药物给药，提供了一种可能对候选药物评价有用的行为分配的相关依赖性测量。与海洛因或可卡因等其他滥用药物相比，临床前甲基苯丙胺与食物选择程序是最近的发展。我们假设，临床前到临床的可转换性将得到改善，通过评价重复的药物治疗对甲基苯丙胺自我管理下的甲基苯丙胺与食物选择程序的影响。为了支持这一假设，文献综述表明，在非人灵长类动物中，临床前药物治疗对甲基苯丙胺与食物选择的影响与人类实验室研究中甲基苯丙胺自我给药的临床药物治疗影响或临床试验中甲基苯丙胺滥用指标之间存在强烈的一致性。总之，这一文献表明，临床前甲基苯丙胺与食物选择程序可能是有用的甲基苯丙胺使用障碍的创新药物疗法的发展。
Substance use disorders are diagnosed as a manifestation of inappropriate behavioral allocation towards abused drugs and away from other behaviors maintained by more adaptive nondrug reinforcers (e.g., work and social relationships). Substance use disorder treatment goals include not only decreasing drug-maintained behavior but also promoting behavioral reallocation toward these socially adaptive alternative reinforcers. Preclinical drug self-administration procedures that offer concurrent access to both drug and nondrug reinforcers provide a translationally relevant dependent measure of behavioral allocation that may be useful for candidate medication evaluation. In contrast to other abused drugs, such as heroin or cocaine, preclinical methamphetamine versus food choice procedures have been a more recent development. We hypothesize that preclinical to clinical translatability would be improved by the evaluation of repeated pharmacological treatment effects on methamphetamine self-administration under a methamphetamine versus food choice procedure. In support of this hypothesis, a literature review suggests strong concordance between preclinical pharmacological treatment effects on methamphetamine versus food choice in nonhuman primates and clinical medication treatment effects on methamphetamine self-administration in human laboratory studies or methamphetamine abuse metrics in clinical trials. In conclusion, this literature suggests preclinical methamphetamine versus food choice procedures may be useful in developing innovative pharmacotherapies for methamphetamine use disorder.