Deregulation and Therapeutic Potential of the Hippo Pathway in Cancer
Deregulation and Therapeutic Potential of the Hippo Pathway in Cancer
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DOI：
10.1146/annurev-cancerbio-030617-050202
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Guan, Kun-Liang
中科院分区：
文献类型：
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作者：
Lin, Kimberly C.;Park, Hyun Woo;Guan, Kun-Liang
在过去的十年中，Hippo通路因其在细胞生长、分化、器官大小和组织稳态调节中的作用而引起越来越多的兴趣。最近的研究扩大了我们对已知的Hippo通路上游调控因子的了解，并一致表明Hippo通路通过接收来自广泛上游信号的输入，对于将细胞信号转化为转录反应至关重要。Hippo通路失调后的戏剧性过度生长表型促使研究其在癌症中的作用。在这里，我们提供了一个概述的Hippo通路，我们目前的理解，其在肿瘤发生中的作用，和潜在的治疗靶向Hippo信号。
The Hippo pathway has drawn increasing interest in the past decade for its role in the regulation of cell growth, differentiation, organ size, and tissue homeostasis. Recent studies have expanded our knowledge of known upstream regulators of the Hippo pathway and have consistently demonstrated that the Hippo pathway is critical for translating cellular cues into transcriptional responses by receiving input from a wide range of upstream signals. Dramatic overgrowth phenotypes upon deregulation of the Hippo pathway have prompted investigation into its role in cancer. Here we provide an overview of the Hippo pathway, our current understanding of its role in tumorigenesis, and potential therapeutics targeting Hippo signaling.