Substances that can change alternative splice-site selection
Substances that can change alternative splice-site selection
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DOI：
10.1042/bst0360483
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发表时间：
2008-06-01
影响因子：
3.9
通讯作者：
Stamm, Stefan
中科院分区：
文献类型：
--
作者：
Sumanasekera, Chiranthani;Watt, David S.;Stamm, Stefan
选择性前 mRNA 剪接是真核基因表达的重要元素，因为大多数蛋白质编码基因使用此过程从单个基因生成多种蛋白质亚型。现在，越来越多的人类疾病被认为是由选择“错误”的替代外显子引起的。过去几年的研究发现了许多可以改变替代外显子使用的低分子量化学物质。大多数这些物质通过阻断组蛋白脱乙酰酶或干扰剪接因子的磷酸化来发挥作用。剩余的大量这些物质如何影响剪接尚不完全清楚。这些低分子量物质的出现不仅为研究替代性前mRNA剪接提供了探针，而且还为利用这些化合物作为药物来控制因选择“错误”剪接位点而引起的疾病打开了大门。
Alternative pre-mRNA splicing is an important element in eukaryotic gene expression, as most of the protein-coding genes use this process to generate multiple protein isoforms from a single gene. An increasing number of human diseases are now recognized to be caused by the selection of 'wrong' alternative exons. Research during the last few years identified a number of low-molecular-mass chemical substances that can change alternative exon usage. Most of these substances act by either blocking histone deacetylases or by interfering with the phosphorylation of splicing factors. How the remaining large number of these substances affect splicing is not yet fully understood. The emergence of these low-molecular-mass substances provides not only probes for studying alternative pre-mRNA splicing, but also opens the door to the possible harnessing of these compounds as drugs to control diseases caused by the selection of 'wrong' splice sites.