2D and 3D real-time passive cavitation imaging of pulsed cavitation ultrasound therapy in moving tissues
2D and 3D real-time passive cavitation imaging of pulsed cavitation ultrasound therapy in moving tissues
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DOI：
10.1088/1361-6560/aaef68
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发表时间：
2018-12-01
影响因子：
3.5
通讯作者：
Pernot, Mathieu
中科院分区：
文献类型：
--
作者：
Escudero, Daniel Suarez;Goudot, Guillaume;Pernot, Mathieu
脉冲空化超声治疗(PCUT)是一种有效的非侵入性治疗方法，在各种医学适应症中依赖于空化气泡产生的机械效应。尽管受到对比度差的限制，传统的B型超声成像已被广泛用于指导和监测治疗过程，使空化泡云得以可视化。然而，气泡云的可视化往往局限于肝脏和心脏等深层器官，而且对于操作员来说仍然完全是主观的。我们的目标是开发一种新的成像模式来更好地识别空化云。目前已经开发了主动和被动空化成像方法，但没有一种方法能够实时定位PCUT产生的空化气泡和运动器官中的空化气泡。本文提出了一种结合时空奇异值分解滤波的被动超声成像方法，用于探测和绘制高灵敏度、高对比度的气泡云，在最大运动速度为10 mm S(-1)的运动应用中，被动空化成像的对比度噪声比主动空化成像高10倍，时间分辨率约为100ms。气泡云的映射可以实时覆盖到传统的B-模式，这允许定位与解剖图像相关的空化现象。最后，我们将该技术扩展到体积成像中，并证明了其在运动模型上的可行性。
Pulsed cavitation ultrasound therapy (PCUT) is an effective non-invasive therapeutic approach in various medical indications that relies on the mechanical effects generated by cavitation bubbles. Even though limited by the poor contrast, conventional ultrasound B-Mode imaging has been widely used for the guidance and monitoring of the therapeutic procedure, allowing the visualization of the cavitation bubble cloud. However, the visualization of the bubble cloud is often limited in deep organs such as the liver and the heart and remains moreover completely subjective for the operator. Our goal is to develop a new imaging mode to better identify the cavitation cloud.Active and passive cavitation imaging methods have been developed but none of them has been able to locate the cavitation bubble created by PCUT in real-time and in moving organs. In this paper we propose a passive ultrasound imaging approach combined with a spatiotemporal singular value decomposition filter to detect and map the bubble cloud with high sensitivity and high contrast.In moving applications at a maximal motion speed of 10 mm s(-1), the contrast-to-noise ratio for passive cavitation imaging is up to 10 times higher than for active cavitation imaging, with a temporal resolution of about 100 ms. The mapping of the bubble cloud can be overlaid in real-time to the conventional B-Mode, which permits to locate the cavitation phenomena in relation to the anatomic image. Finally, we extend the technique to volumetric imaging and show its feasibility on moving phantoms.