Temperature-modulated fluorescence tomography in a turbid media
Temperature-modulated fluorescence tomography in a turbid media
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DOI：
10.1063/1.3681378
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发表时间：
2012-02-13
影响因子：
4
通讯作者：
Gulsen, Gultekin
中科院分区：
文献类型：
--
作者：
Lin, Yuting;Bolisay, Linden;Gulsen, Gultekin
生物组织中的高散射使得厚介质中的荧光层析成像逆问题非常具有挑战性。我们描述了一种称为“温度调制荧光断层扫描”的方法，它可以在聚焦超声分辨率下获得荧光图像。通过利用最近出现的温度敏感的荧光造影剂，该技术提供了荧光图像的高分辨率之前的任何重建过程。我们证明，这种技术非常适合于解决位于几厘米深的组织中的小荧光目标。(C)2012年美国物理学会。[doi：10.1063/1.3681378]
High scattering in biological tissues makes fluorescence tomography inverse problem very challenging in thick medium. We describe an approach termed "temperature-modulated fluorescence tomography" that can acquire fluorescence images at focused ultrasound resolution. By utilizing recently emerged temperature sensitive fluorescence contrast agents, this technique provides fluorescence images with high resolution prior to any reconstruction process. We demonstrate that this technique is well suited to resolve small fluorescence targets located several centimeters deep in tissue. (C) 2012 American Institute of Physics. [doi:10.1063/1.3681378]