Extraction mechanism of sulfamethoxazole in water samples using aqueous two-phase systems of poly(propylene glycol) and salt.
Extraction mechanism of sulfamethoxazole in water samples using aqueous two-phase systems of poly(propylene glycol) and salt.
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DOI：
10.1016/j.aca.2010.12.012
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发表时间：
2011-02
影响因子：
6.2
通讯作者：
Xueqiao Xie;Yun Wang;Juan Han;Yongsheng Yan
中科院分区：
文献类型：
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作者：
Xueqiao Xie;Yun Wang;Juan Han;Yongsheng Yan
基于聚丙二醇400（PPG 400）-盐双水相体系（ATPS），提出了一种绿色、经济、有效的样品前处理技术与高效液相色谱联用分离测定磺胺甲恶唑（SMX）。在PPG 400-盐ATPS体系中SMX的萃取率受多种因素的影响，包括盐的种类、盐的量、pH和温度。在最佳条件下，大部分SMX被分配到富聚合物相，平均萃取率为99.2%，这可能是由于疏水作用和盐析效应。该萃取技术已成功应用于真实的水样中SMX的分析，回收率为96.0- 100.6%，检出限为0.1μgL−1，线性范围为2.5-250.0μgL−1。
Based on the poly(propylene glycol)400(PPG400)–salt aqueous two-phase system (ATPS), a green, economical and effective sample pretreatment technique coupled with high performance liquid chromatography was proposed for the separation and determination of sulfamethoxazole (SMX). The extraction yield of SMX in PPG400–salt ATPS is influenced by various factors, including the salt species, the amount of salt, pH, and the temperature. Under the optimum conditions, most of SMX was partitioning into the polymer-rich phase with the average extraction efficiency of 99.2%, which may be attributed to the hydrophobic interaction and salting-out effect. This extraction technique has been successfully applied to the analysis of SMX in real water samples with the recoveries of 96.0–100.6%, the detection limits of 0.1μgL−1, and the linear ranges of 2.5–250.0μgL−1.