The HLA a2/6802 supertype is associated with reduced risk of perinatal human immunodeficiency virus type 1 transmission
The HLA a2/6802 supertype is associated with reduced risk of perinatal human immunodeficiency virus type 1 transmission
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DOI：
10.1086/318092
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发表时间：
2001-02-01
影响因子：
6.4
通讯作者：
Plummer, FA
中科院分区：
文献类型：
--
作者：
MacDonald, KS;Embree, JE;Plummer, FA
某些HLA可以通过呈递保守的免疫原性表位用于T细胞识别来部分地解释人类免疫缺陷病毒1型（HIV-1）易感性的差异。HLA超型A2/6802与性工作者对HIV-1易感性降低相关该超型中的等位基因在某些情况下呈现相同的HIV-1肽表位用于T细胞识别。本研究旨在确定HLAA 2/6802超型是否影响肯尼亚HIV-1感染母亲和儿童的HIV-1传播。围产期HIV-1感染风险的降低与相关HLA等位基因的功能簇（称为A2/6802超型）密切相关（比值比，0.12; 95%置信区间，0.03-0.54; P = 0.006）。这种作用是独立的母-子HLA不一致的保护作用。这些数据提供了进一步的证据表明HLA超型与HIV-1传播的不同易感性相关。
Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibility to HIV-1 among sex workers. The alleles in this supertype present the same HIV-1 peptide epitopes for T cell recognition in some cases. This study sought to determine whether the HLAA2/6802 supertype influenced HIV-1 transmission in a prospective cohort of HIV-1-infected mothers and children in Kenya. Decreased perinatal HIV-1 infection risk was strongly associated with possession of a functional cluster of related HLA alleles, called the A2/6802 supertype (odds ratio, 0.12; 95% confidence interval, 0.03-0.54; P = .006). This effect was independent of the protective effect of maternal-child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV-1 transmission.