Specific human B lymphocyte alloantigens linked to HL-A.
Specific human B lymphocyte alloantigens linked to HL-A.
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与 HL-A 相关的特定人 B 淋巴细胞同种抗原。
DOI：
10.1073/pnas.72.12.5103
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发表时间：
1975
影响因子：
11.1
通讯作者：
D. Amos
中科院分区：
文献类型：
--
作者：
D. Mann;L. Abelson;P. Henkart;S. Harris;D. Amos
先前发现与B淋巴培养细胞特异性反应的血清在微量细胞毒性试验中对分离的T和B外周血淋巴细胞进行了测试。对从几个大的阿米什家庭获得的淋巴细胞进行了研究。这些研究中使用的血清对外周血、B淋巴细胞具有细胞毒性，但对T淋巴细胞无细胞毒性。检测到的抗原符合HL-A单倍型的遗传模式。与HL-A抗原的强连锁不平衡表明控制B淋巴细胞抗原表达的基因与控制HL-A同种异体抗原的基因连锁。
Sera, previously found to react specifically with B lymphoid cultured cells, were tested on isolated T and B peripheral blood lymphocytes in a microcytotoxicity assay. Studies were performed on lymphocytes obtained from several large Amish families. The sera used in these studies were cytotoxic to peripheral blood, B lymphocytes, but not cytotoxic to T lymphocytes. The antigens detected followed the inheritance pattern of HL-A haplotypes. The strong linkage disequilibrium with HL-A antigens suggests that genes controlling the expression of B lymphocyte antigens are linked to genes controlling HL-A alloantigens.