Imaging of matrix metalloproteinase activation and left ventricular remodeling.
Imaging of matrix metalloproteinase activation and left ventricular remodeling.
复制标题
基质金属蛋白酶激活和左心室重塑的成像。
DOI：
10.1007/bf02938340
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发表时间：
2007
影响因子：
3.7
通讯作者：
Sinusas,AlbertJ
中科院分区：
文献类型：
--
作者：
Chung,Grace;Sinusas,AlbertJ
虽然左心室（LV）重塑可能是适应性的心脏损伤的早期阶段，持续重塑是一个病理过程，与预后不良和心功能下降。基质金属蛋白酶（MMP）是一个蛋白水解酶家族，参与心肌细胞外蛋白的降解，并与不良心脏重塑有关。有越来越多的文献支持特定的基质金属蛋白酶在心脏重塑的动物模型和临床研究中的作用。常规的生理指标成像，如灌注和功能，已被用来监测左心室重塑。最近，MMPs靶向成像的潜在优势已被证明，特别是如果这与生理成像有关。
Although left ventricular (LV) remodeling may be adaptive in early phases of cardiac injury, continued remodeling is a pathologic process that is associated with poor prognosis and diminished cardiac function. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes involved in the degradation of myocardial extracellular proteins and have been implicated in adverse cardiac remodeling. There is a growing body of literature that supports the role of specific MMPs in cardiac remodeling in both animal models and clinical studies. Conventional imaging of physiologic indices, such as perfusion and function, have been used to monitor LV remodeling. Recently, the potential, advantage of targeted imaging of MMPs has been demonstrated, particularly if this is linked with physiologic imaging.