Hypercortisolemia and depression

Hypercortisolemia and depression
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DOI:
10.1097/01.psy.0000163456.22154.d2
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发表时间:
2005-05-01
影响因子:
3.3
通讯作者:
Nemeroff, CB
Nemeroff, CB
中科院分区:
医学3区
文献类型:
--
作者:
Gillespie, CF;Nemeroff, CB

文献摘要

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高皮质醇血症和下丘脑-垂体-肾上腺(HPA)轴的失调常见于严重形式的抑郁症。作者回顾了用于评估下丘脑轴功能的技术的历史,高皮质醇血症作为抑郁症的一种状态而不是特征成分的证据,以及治疗意义。
Hypercortisolemia and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis are often found in severe forms of depression. The authors review the history of techniques used to assess the functions of the HPA axis, evidence for hypercortisolemia as a state rather than trait component of depression, and treatment implications.