A Research Module for the Organic Chemistry Laboratory: Multistep Synthesis of a Fluorous Dye Molecule
A Research Module for the Organic Chemistry Laboratory: Multistep Synthesis of a Fluorous Dye Molecule
复制标题
有机化学实验室的研究模块：含氟染料分子的多步合成
作者：
Michael C. Slade;J. Raker;Brandon M. Kobilka;N. Pohl
一个多会话的研究型模块已被开发用于本科有机教学实验室课程。学生的任务是规划和执行一种新型氟染料分子的合成，并使用它来探索氟亲和色谱分离技术，这是该技术在教学实验室的第一次实施。该项目的关键要素包括逐步向学生介绍化学文献的使用，以促进他们的搜索，以及故意的限制，旨在迫使他们批判性地思考有机化学中的反应设计和优化。该项目还向学生介绍了一些先进的实验室实践，如Schlenk技术，反应混合物的脱气，亲和色谱法和微波辅助化学。这为学生提供了一个教学实验室的经验，密切反映了真实的合成有机化学实验室在世界各地的实践。
A multi-session research-like module has been developed for use in the undergraduate organic teaching laboratory curriculum. Students are tasked with planning and executing the synthesis of a novel fluorous dye molecule and using it to explore a fluorous affinity chromatography separation technique, which is the first implementation of this technique in a teaching laboratory. Key elements of the project include gradually introducing students to the use of the chemical literature to facilitate their searching, as well as deliberate constraints designed to force them to think critically about reaction design and optimization in organic chemistry. The project also introduces students to some advanced laboratory practices such as Schlenk techniques, degassing of reaction mixtures, affinity chromatography, and microwave-assisted chemistry. This provides students a teaching laboratory experience that closely mirrors authentic synthetic organic chemistry practice in laboratories throughout the world.
用于氟分离应用的氟探针分子的合成和固态结构。
影响因子：
2.1
作者：
Lehmler,H-J;Telu,S;Vyas,SM;Shaikh,NS;Rankin,SE;Knutson,BL;Parkin,S
通讯作者：
Parkin,S