INCIDENCE OF TDT POSITIVITY IN CASES OF LEUKEMIA AND LYMPHOMA
INCIDENCE OF TDT POSITIVITY IN CASES OF LEUKEMIA AND LYMPHOMA
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DOI：
10.1159/000206072
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发表时间：
1986-01-01
影响因子：
2.4
通讯作者：
MINOWADA, J
中科院分区：
文献类型：
--
作者：
DREXLER, HG;MENON, M;MINOWADA, J
应用免疫荧光法检测了333例不同类型和亚型白血病和淋巴瘤细胞中酶标志物末端脱氧核苷酸转移酶（TdT）的表达。90%以上的cALL和T-ALL、70%以上的Null-ALL和80%以上的pre-B-ALL TdT阳性。TdT阴性的B-ALL中1例TdT阳性。所有成熟B细胞恶性肿瘤（B-CLL、毛细胞白血病、B细胞淋巴瘤）病例均为TdT阴性。在成熟T细胞恶性肿瘤组中，T-CLL和蕈样肉芽肿阴性，6例成熟T细胞淋巴瘤中有2例TdT阳性。13%的急性髓系白血病和36%的CML急变期表达TdT。因此，这些TdT阳性的CML急变期病例也携带共同的ALL抗原，属于淋巴亚型。CML和红白血病均为TdT阴性。TdT已成为未成熟淋巴样白血病细胞的不可或缺的指标，并且作为白血病表型中使用的标志物组的一部分特别有价值。
The expression of the enzyme marker terminal deoxynucleotidyl transferase (TdT) was examined by immunofluorescence assay in the cells from 333 cases with various types and subtypes of leukemia or lymphoma. More than 90% of cALL and T-ALL, 70% of Null-ALL and 80% of pre-B-ALL were TdT-positive. One case in the commonly TdT-negative group of B-ALL showed TdT-positive cells. All cases of mature B-cell malignancies (B-CLL, hairy cell leukemia, B-cell lymphoma) have been TdT-negative. In the group of mature T-cell malignancies, T-CLL and mycosis fungoides were negative and 2 out of 6 mature T-cell lymphomas were TdT-positive. 13% of acute myeloid leukemias and 36% of CML in blast crisis expressed TdT. Therefore, these TdT-positive cases of CML in blast crisis also carrying the common ALL-antigen belong to the lymphoid subtype. CML and erythroleukemia were invariably TdT-negative. TdT has become an indispensable indicator of immature lymphoid leukemia cells and is particularly valuable as part of the panel of markers used in leukemia phenotyping.