Hydrostatic and oncotic determinants of microvascular fluid balance in normal canine joints.
Hydrostatic and oncotic determinants of microvascular fluid balance in normal canine joints.
复制标题
正常犬关节微血管液体平衡的静水压和胶体渗透压决定因素。
DOI：
10.1002/art.1780330110
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发表时间：
1990
影响因子：
--
通讯作者：
Benedict,RS
中科院分区：
文献类型：
--
作者：
Simkin,PA;Benedict,RS
水在血浆 (p) 和滑液 (SF) 之间移动，以响应相反的静水压 (HP) 和胶体渗透压 (OP) 平衡中的梯度。在近端过滤停止和远端重吸收开始的血管部位，所有力理论上都是平衡的。此时，可以根据方程TMP=HPSF+OPp-OPSF来估计过渡微血管压力(TMP)。我们测量了 10 只 2-10 岁正常狗的肩膀、手腕和膝盖的力。膝部的平均 HPS 低于肩部的平均 HPS，并且显着低于腕部的 HPS。相反，手腕处的 OPSFin 明显低于肩部或膝盖处的 OPSFin。这些因素综合表明，正常膝关节的微血管床的平均 TMP 非常低（7.9 毫米汞柱）。我们还发现每只狗的年龄与其 SF 的平均胶体渗透压之间存在很强的正相关性。
Water moves between plasma (p) and synovial fluid (SF) in response to gradients in the balance of opposing hydrostatic pressures (HP) and oncotic pressures (OP). At the vascular site where proximal filtration ceases and distal reabsorption begins, all forces are theoretically in balance. At this point, the transitional microvascular pressure (TMP) may be estimated from the equation TMP = HPSF+ OPp− OPSF. We measured these forces in the shoulders, wrists, and knees of 10 normal dogs, ages 2–10 years. The mean HPSFin the knee was lower than that in the shoulders and significantly lower than that in the wrist. Conversely, the OPSFin the wrist was significantly lower than that in the shoulder or the knee. These factors combined indicate that the microvascular bed in the normal knee has a remarkably low mean TMP (7.9 mm Hg). We also found a strong positive correlation between the age of each dog and the mean oncotic pressure of its SF.