WHAT ROLE DOES THE EXTRACELLULAR-MATRIX SERVE IN SKIN-GRAFTING AND WOUND-HEALING
WHAT ROLE DOES THE EXTRACELLULAR-MATRIX SERVE IN SKIN-GRAFTING AND WOUND-HEALING
复制标题
DOI：
10.1016/0305-4179(94)90094-9
复制
发表时间：
1994-01-01
期刊：
影响因子：
2.7
通讯作者：
MACNEIL, S
中科院分区：
文献类型：
--
作者：
MACNEIL, S
最近对细胞外基质（ECM）的结构和组成的研究强烈表明，这种基质的主要作用是调节细胞/细胞通讯，而不是被动地支持细胞。大量关于ECM的结构数据表明，这些蛋白质内存在特定的序列排列，其深刻地影响在该区域中移动的细胞的行为，关于附着、迁移、分化和增殖。在皮肤中，ECM可以被认为促进角质形成细胞和成纤维细胞之间的“适当”通信。皮肤ECM可被认为由主要由成纤维细胞产生的大的不溶性蛋白质和可由成纤维细胞或角质形成细胞产生并附着于ECM的可溶性蛋白质组成。大的不溶性蛋白质和较小的可溶性蛋白质都可构成影响角质形成细胞行为的信号。在皮肤移植中需要真皮成分的临床意识突出了需要进一步研究ECM影响角质形成细胞/成纤维细胞生物学的方式。这样的研究将被证明与理解移植物吸收、移植物挛缩和瘢痕形成的问题有关。
Recent research on the structure and composition of the extracellular matrix (ECM) now strongly indicates that the major role of this matrix is in regulating cell/cell communication rather than in passively supporting cells. A wealth of structural data on the ECM suggests that there are specific arrangements of sequences within these proteins which profoundly influence the behaviour of the cells moving in that area, with respect to attachment, migration, differentiation and proliferation. In the skin, the ECM can be argued to promote 'appropriate' communication between the keratinocyte and the fibroblast. Skin ECM can be considered to consist both of the large insoluble proteins produced primarily by the fibroblasts, and soluble proteins which may be produced by fibroblasts or keratinocytes and become attached to the ECM Both the large insoluble and the smaller soluble proteins may constitute signals which influence the behaviour of the keratinocytes. The clinical awareness of the need for a dermal component in skin grafting highlights the need for further research into the way in which the ECM influences keratinocyte/fibroblast biology. Such research will prove relevant to understanding the problems of graft take, graft contracture and scarring.