Molecular targeting for malignant gliomas (Review).
Molecular targeting for malignant gliomas (Review).
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DOI：
10.3892/ijo.24.5.1101
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发表时间：
2004-05
影响因子：
5.2
通讯作者：
Y. Kondo;E. F. Hollingsworth;S. Kondo
中科院分区：
文献类型：
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作者：
Y. Kondo;E. F. Hollingsworth;S. Kondo
恶性胶质瘤具有快速侵袭脑的倾向，对包括放射和化学疗法在内的常规治疗非常抵抗。遗传和分子生物学技术的最新进展使得恶性胶质瘤的特征性分子谱的确定成为可能。本文根据与胶质母细胞瘤组织密切相关的分子列表，综述了针对这些分子的治疗策略。广泛研究的靶分子包括EGFR、PTEN、端粒酶和Ras/Raf/MAPK和PI 3 K/Akt/mTOR通路的信号通路调节剂。靶向特定分子的治疗可以有效地杀死肿瘤细胞，同时保持正常细胞的完整。
With tendency to invade rapidly in the brain, malignant gliomas are very resistant to conventional therapies including radiation and chemotherapy. Recent advances in genetic and molecular techniques have made it possible to define characteristic molecular profiles of malignant gliomas. Based on the list of the molecules closely related to glioblastoma tissues, we reviewed strategies targeting them. Target molecules extensively studied include EGFR, PTEN, telomerase and signal pathway modulators for Ras/Raf/MAPK and PI3K/Akt/mTOR pathways. Therapies targeting specific molecules may result in killing tumor cells effectively while keeping normal cells intact.