Cytochalasin-B: time-lapse cinematographic studies on its effects on cytokinesis.
Cytochalasin-B: time-lapse cinematographic studies on its effects on cytokinesis.
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细胞切拉斯蛋白-B：有关其对细胞因子的影响的延时摄影研究。
DOI：
10.1083/jcb.54.3.657
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发表时间：
1972-09
期刊：
影响因子：
--
通讯作者：
Krishan A
中科院分区：
文献类型：
--
作者：
Krishan A
L细胞暴露于细胞松弛素-B（cyto-B）时，在双极和多极细胞分裂中都显示出正常的深分裂沟。由于药物诱导的细胞运动抑制，所产生的子细胞不会彼此远离，而是重新结合形成多核细胞。在有丝分裂的细胞从文化暴露于细胞B长时间，强烈起泡和收缩的细胞表面被视为从延时研究的证据表明，细胞B诱导的多核细胞的形成，而不是由分裂沟的失败，但由药物诱导的变化，在分裂后的细胞表面活性和运动。
L cells exposed to cytochalasin-B (cyto-B) show the normal development of deep cleavage furrows in both bipolar and multipolar cell divisions Due to the drug-induced inhibition of cellular motility, the resulting daughter cells do not move away from each other but reunite to form multinucleate cells. In mitotic cells from cultures exposed to cyto-B for long periods of time, vigorous blebbing and contraction of the cell surface is seen The evidence from time-lapse studies presented suggests that cyto-B-induced multinucleate cells are formed, not by the failure of the cleavage furrow, but by the drug-induced changes in surface activity and motility of cells after division.