Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems
Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems
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DOI：
10.1002/psp4.12042
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发表时间：
2015-10-01
影响因子：
3.5
通讯作者：
Lauffenburger, D. A.
中科院分区：
文献类型：
--
作者：
Stokes, C. L.;Cirit, M.;Lauffenburger, D. A.
微生理系统（MPS）或芯片上的生理组的扩展可以说是两个相互关联的、基于建模的活动：平台上扩展和体内体外翻译。这种双重方法减少了完美重新调整和模拟体内生理学的需要，这种愿望既极具挑战性，又没有实质性意义，因为任何特定生理条件的相关性都不确定。因此，这一观点提供了一种易于处理的方法来设计相互作用的 MPS 并将体外结果与体内的类似情况相关联。
Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation. This dual approach reduces the need to perfectly rescale and mimic in vivo physiology, an aspiration that is both extremely challenging and not substantively meaningful because of uncertain relevance of any specific physiological condition. Accordingly, this perspective offers a tractable approach for designing interacting MPSs and relating in vitro results to analogous context in vivo.