Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.
Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.
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DOI：
10.1111/1574-6976.12047
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发表时间：
2014-05
影响因子：
11.3
通讯作者：
Chater KF
中科院分区：
文献类型：
--
作者：
Chandra G;Chater KF
为了阐明放线菌复杂性的进化和机制，我们评估了已知链霉菌发育基因的分布和起源以及放线菌特异性基因的发育意义。作为辅助手段，我们建立了一个关于冷色链霉菌基因组与100多种其他放线菌基因组之间互生最佳命中的放线菌数据库（http://streptomyces.org.uk/actinoblast/）。我们认为，形态复杂性的出现是由早期放线菌的特殊特征所支撑的，例如极性生长和调节Wbl蛋白和氧化还原保护巯基菌硫醇在生理应激生长转变过程中产生的瞬时一氧化氮信号的耦合参与。似乎早期放线菌的一些细胞生长和分裂蛋白对复杂放线菌的产孢比对菌丝生长更重要，在复杂放线菌中，间隔很少，与细胞完全分离无关。具有结构作用的细胞外蛋白的获得，高度调控的细胞外蛋白酶级联，以及额外的调控基因，允许早期放线菌固定阶段过程在菌丝垫中空生菌丝的出现和孢子链的形成中重新部署。这些细胞外蛋白可能有助于物种形成。形态多样的进化枝中较简单的成员失去了一些发育基因。
To illuminate the evolution and mechanisms of actinobacterial complexity, we evaluate the distribution and origins of known Streptomyces developmental genes and the developmental significance of actinobacteria-specific genes. As an aid, we developed the Actinoblast database of reciprocal blastp best hits between the Streptomyces coelicolor genome and more than 100 other actinobacterial genomes (http://streptomyces.org.uk/actinoblast/). We suggest that the emergence of morphological complexity was underpinned by special features of early actinobacteria, such as polar growth and the coupled participation of regulatory Wbl proteins and the redox-protecting thiol mycothiol in transducing a transient nitric oxide signal generated during physiologically stressful growth transitions. It seems that some cell growth and division proteins of early actinobacteria have acquired greater importance for sporulation of complex actinobacteria than for mycelial growth, in which septa are infrequent and not associated with complete cell separation. The acquisition of extracellular proteins with structural roles, a highly regulated extracellular protease cascade, and additional regulatory genes allowed early actinobacterial stationary phase processes to be redeployed in the emergence of aerial hyphae from mycelial mats and in the formation of spore chains. These extracellular proteins may have contributed to speciation. Simpler members of morphologically diverse clades have lost some developmental genes.
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影响因子：
3.2
作者：
Ainsa, JA;Ryding, NJ;Chater, KF
通讯作者：
Chater, KF
影响因子：
3.2
作者：
Bibb, MJ;Molle, V;Buttner, MJ
通讯作者：
Buttner, MJ
影响因子：
3.6
作者：
Capstick, David S.;Willey, Joanne M.;Elliot, Marie A.
通讯作者：
Elliot, Marie A.
影响因子：
3.2
作者：
Bennett, Jennifer A.;Aimino, Rachel M.;McCormick, Joseph R.
通讯作者：
McCormick, Joseph R.
影响因子：
7
作者：
Barabote, Ravi D.;Xie, Gary;Berry, Alison M.
通讯作者：
Berry, Alison M.