Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches.
Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches.
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DOI：
10.3389/fimmu.2020.573326
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发表时间：
2020
影响因子：
7.3
通讯作者：
Welsh JW
中科院分区：
文献类型：
--
作者：
Klein K;He K;Younes AI;Barsoumian HB;Chen D;Ozgen T;Mosaffa S;Patel RR;Gu M;Novaes J;Narayanan A;Cortez MA;Welsh JW
线粒体在癌症形成和发展中的作用已被广泛研究，但关于这种复杂的关系仍有许多需要了解。线粒体调节许多已知在癌细胞中发生变化的过程，从新陈代谢到氧化应激再到细胞凋亡。在这里，我们回顾了对线粒体在癌细胞中作用的不断发展的认识，并强调了支持线粒体在癌症免疫逃避中的作用以及线粒体靶向抗肿瘤治疗的效果的关键证据。还考虑了如何利用线粒体在癌症中的作用的知识来设计和改进癌症治疗，特别是免疫治疗和放射治疗。我们进一步对线粒体影响肿瘤免疫反应的机制提供了重要的见解，不仅在癌细胞中，而且在免疫细胞中。鉴于线粒体在癌症和免疫系统之间复杂相互作用中的核心作用，应高度重视制定合理的策略，将线粒体作为未来临床前和临床研究的潜在靶点。我们认为，靶向线粒体可能会为新的抗肿瘤药物的开发提供更多的机会。
The role of mitochondria in cancer formation and progression has been studied extensively, but much remains to be understood about this complex relationship. Mitochondria regulate many processes that are known to be altered in cancer cells, from metabolism to oxidative stress to apoptosis. Here, we review the evolving understanding of the role of mitochondria in cancer cells, and highlight key evidence supporting the role of mitochondria in cancer immune evasion and the effects of mitochondria-targeted antitumor therapy. Also considered is how knowledge of the role of mitochondria in cancer can be used to design and improve cancer therapies, particularly immunotherapy and radiation therapy. We further offer critical insights into the mechanisms by which mitochondria influence tumor immune responses, not only in cancer cells but also in immune cells. Given the central role of mitochondria in the complex interactions between cancer and the immune system, high priority should be placed on developing rational strategies to address mitochondria as potential targets in future preclinical and clinical studies. We believe that targeting mitochondria may provide additional opportunities in the development of novel antitumor therapeutics.
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发表时间：
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影响因子：
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作者：
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