SENSATIONS EVOKED BY INTRANEURAL MICROSTIMULATION OF C NOCICEPTOR FIBERS IN HUMAN-SKIN NERVES
SENSATIONS EVOKED BY INTRANEURAL MICROSTIMULATION OF C NOCICEPTOR FIBERS IN HUMAN-SKIN NERVES
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DOI：
10.1113/jphysiol.1989.sp017737
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发表时间：
1989-08-01
影响因子：
5.5
通讯作者：
TOREBJORK, E
中科院分区：
文献类型：
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作者：
OCHOA, J;TOREBJORK, E
1.根据显微神经造影术（MNG）神经内记录的皮肤刺激反应特征，识别出71个为清醒人类志愿者四肢无毛和多毛皮肤提供神经刺激的C多模式伤害感受器。绝大多数这样的单位主要是在神经内微刺激（INMS）的基础上的主观质量和皮肤定位诱发疼痛的感觉。电生理学研究补充了严格的心理物理测试在神经内C记录网站提供微刺激。2.单个C伤害性感受器单位的传导速度可以被示出为在用于意识感觉的阈值强度下的重复INMS之后暂时减慢。这种“标记”证明了通过记录识别的特定C单元在INMS和心理物理测试期间被有效激活。3.从主观质量，时间属性和本地化的投影心理学估计的认知属性，从C记录网站的INMS在阈值强度的感知。生理单位类型（C多模态伤害感受器）与诱发感觉的主观质量（钝痛或烧灼痛）有显著的匹配性。此外，有显着的空间匹配的感受野从C记录点由INMS提供的有意识的感觉阈值强度诱发的疼痛感觉。4.分离的A神经纤维块造成的压缩缺血没有取消的感觉烧灼疼痛投射到毛茸茸的皮肤，诱发INMS提供在C记录网站。5.虽然（a）主观性质和空间定位与（B）客观生理单一类型和受体定位的双重匹配，加上A阻断的结果，提供了C伤害感受器纤维在INMS期间可以被相当选择性地激活的证据，结果还证明来自人皮肤的C多模态伤害感受器引起延迟的钝痛或烧灼痛，精确地投射到皮肤上的限定位点，即使在空间求和被减小到最小值之后。
1. Seventy-one C polymodal nociceptors supplying glabrous and hairy skin in limbs of awake human volunteers were identified on the basis of cutaneous stimulus-response characteristics recorded intraneurally by microneurography (MNG). The large majority of such units were primarily detected during intraneural microstimulation (INMS) on the basis of subjective quality and cutaneous localization of evoked painful sensation. Electrophysiological studies were supplemented with rigorous psychophysical testing during microstimulation delivered at intraneural C recording sites. 2. The conduction velocity of single C nociceptor units could be shown to become transiently slowed following repetitive INMS at threshold intensity for conscious sensation. Such ''marking'' witnessed tht particular C units, identified by recording, had been effectively activated during INMS and psychophysical testing. 3. Cognitive attributes of sensations evoked from C recording sites by INMS at threshold intensity for perception were estimated psychophysically for subjective quality, temporal attributes and localized projection. There was remarkable matching of physiological unit type (C polymodal nociceptor) with subjective quality of evoked sensation (dull or burning pain). Further, there was remarkable spatial matching of receptive field of the pain sensation evoked from the C recording site by INMS delivered at threshold intensity for conscious sensation. 4. Dissociated A nerve fibre blocks caused by compression-ischaemia did not abolish the sensation of burning pain projected to hairy skin, evoked by INMS delivered at C recording sites. 5. While the double matching of (a) subjective quality and spatial localization with (b) objective physiological unitary type and receptor location, coupled with the results of A blocks, provide evidence that C nociceptor fibres can be fairly selectively activated during INMS, the results also attest that C polymodal nociceptors from human skin evoke delayed dull or burning pain, accurately projected to a defined locus on skin, even after spatial summation is reduced to a minimum.