Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response
Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response
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DOI：
10.1016/j.celrep.2019.05.108
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发表时间：
2019-07-02
期刊：
影响因子：
8.8
通讯作者：
da Costa, Clarissa Prazeres
中科院分区：
文献类型：
--
作者：
Bhattacharjee, Sonakshi;Mejias-Luque, Raquel;da Costa, Clarissa Prazeres
幽门螺杆菌长期在胃中定植，与胃癌密切相关。它与蠕虫如寄生虫的伴随发生与癌症发病率的降低有关，可能是由于抑制了H。幽门相关的促炎反应。然而，缺乏支持这种因果关系或两种病原体相互作用的实验证据。我们研究了在不同免疫阶段的S。曼氏感染。令人惊讶的是，共同感染的小鼠增加了H。幽门螺杆菌胃定植在干扰素γ（IFN γ）阶段的巨噬细胞感染，但减少浸润的T细胞在胃由于误导抗原经验的CXCR 3（+）T细胞的肝脏。出乎意料的是，H。幽门螺杆菌共感染导致对脂质体诱导的肝损伤的部分保护。在这里，我们证明了纤维化保护性IL-13 Ra 2的增加与H.幽门感染因此，我们的研究有力地指出了解剖学上分离的病原体的免疫相互作用，最终导致疾病病理学改变。
Helicobacter pylori chronically colonizes the stomach and is strongly associated with gastric cancer. Its concomitant occurrence with helminths such as schistosomes has been linked to reduced cancer incidence, presumably due to suppression of H. pylori-associated pro-inflammatory responses. However, experimental evidence in support of such a causal link or the mutual interaction of both pathogens is lacking. We investigated the effects of co-infection during the different immune phases of S. mansoni infection. Surprisingly, co-infected mice had increased H. pylori gastric colonization during the interferon gamma (IFN gamma) phase of schistosome infection but reduced infiltration of T cells in the stomach due to misdirection of antigen-experienced CXCR3(+) T cells to the liver. Unexpectedly, H. pylori co-infection resulted in partial protection from schistosome-induced liver damage. Here, we demonstrate that an increase in fibrosis-protective IL-13Ra2 is associated with H. pylori infection. Thus, our study strongly points to an immunological interaction of anatomically isolated pathogens, eventually resulting in altered disease pathology.