Gray Matter Abnormalities in Childhood Maltreatment: A Voxel-Wise Meta-Analysis
Gray Matter Abnormalities in Childhood Maltreatment: A Voxel-Wise Meta-Analysis
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DOI：
10.1176/appi.ajp.2014.13101427
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发表时间：
2014-08-01
影响因子：
17.7
通讯作者：
Rubia, Katya
中科院分区：
文献类型：
--
作者：
Lim, Lena;Radua, Joaquim;Rubia, Katya
目的：童年虐待作为一种严重的压力源，产生一系列生理和神经生物学变化，导致大脑结构的持久改变。然而，结构神经影像学的结果一直不一致。作者对已发表的儿童期虐待全脑基于体素的形态测量学研究进行了荟萃分析，以阐明迄今为止相对于对照受试者最强大的体积灰质异常。方法：包括12个数据集，共有331人有儿童期虐待史的受试者（56名儿童/青少年和275名成人）和362名对照受试者（56名儿童/青少年和306名成人）。使用基于体素的元分析方法--各向异性效应大小符号差分映射，检查相对于对照受试者，受虐待个体中较小和较大的灰质体积区域。与对照组相比，儿童期遭受虐待的个体在右眶额回/上级颞回延伸到杏仁核、杏仁核、杏仁核、杏仁核和杏仁核的灰质体积明显较小，海马旁回、颞中回及左额下回、中央后回。他们在右侧额上上级和左侧枕中回有较大的灰质体积。在未用药参与者的亚组分析中，右眶额颞叶边缘和左下额叶区域的缺陷仍然存在。在左中央后回和中枕回abbills被发现只有在老年人虐待的个人相对于年龄匹配的比较subjects.Conclusions：研究结果表明，最一致的灰质异常暴露于儿童期虐待的个人是在相对较晚的发展腹外侧额前边缘颞区，是已知的调解。晚期发展的情感和认知控制功能，这在这一人群中通常是受损的。
Objective: Childhood maltreatment acts as a severe stressor that produces a cascade of physiological and neurobiological changes that lead to enduring alterations in brain structure. However, structural neuroimaging findings have been inconsistent.. The authors conducted a meta-analysis of published whole-brain voxel-based morphometry studies in childhood maltreatment to elucidate the most robust volumetric gray matter abnormalities relative to comparison subjects to date.Method: Twelve data sets were included, comprising 331 individuals (56 children/adolescents and 275 adults) with a history of childhood maltreatment and 362 comparison subjects (56 children/adolescents and 306 adults). Anisotropic effect size-signed differential mapping, a voxel-based meta-analytic method, was used to examine regions of smaller and larger gray matter volumes in maltreated individuals relative to comparison subjects.Results: Relative to comparison subjects, individuals exposed to childhood maltreatment exhibited significantly smaller gray matter volumes in the right orbitofrontal/superior temporal gyrus extending to the amygdala, insula, and parahippocampal and middle temporal gyri and in the left inferior frontal and postcentral gyri. They had larger gray matter volumes in the right superior frontal and left middle occipital gyri. Deficits in the right orbitofrontal-temporal-limbic and left inferior frontal regions remained in a subgroup analysis of unmedicated participants. Abnormalities in the left postcentral and middle occipital gyri were found only in older maltreated individuals relative to age-matched comparison subjects.Conclusions: The findings demonstrate that the most consistent gray matter abnormalities in individuals exposed to childhood maltreatment are in relatively late-developing ventrolateral prefrontal-limbic-temporal regions that are known to mediate. late-developing functions of affect and cognitive control, which are typically compromised in this population.