In vitro evaluation of the inhibitory action of PGI2 to vasoconstrictions induced by various prostaglandins, serotonin and hemoglobin using the canine basilar artery.
In vitro evaluation of the inhibitory action of PGI2 to vasoconstrictions induced by various prostaglandins, serotonin and hemoglobin using the canine basilar artery.
复制标题
使用犬基底动脉体外评估 PGI2 对各种前列腺素、血清素和血红蛋白诱导的血管收缩的抑制作用。
DOI：
10.2176/nmc.22.507
复制
发表时间：
1982
影响因子：
1.9
通讯作者：
K. Takakura
中科院分区：
文献类型：
--
作者：
T. Asano;T. Sasaki;C. Ochiai;K. Takakura
Current investigations have indicated that prolonged vasoconstriction in vasospasm following subarachnoid hemorrhage due to rupture of intracranial aneurysms is the result of a combined action of various vasoconstrictive agents such as serotonin, oxyhemoglobin, thrombin and prostaglandins. PGI2 (prostacyclin), on the other hand, has been known to possess antagonistic actions to some of the above agents. To elucidate the role of PGI2 as a natural protecting factor against the occurrence of vasospasm, its inhibitory action against vasoconstrictions induced by serotonin, oxyhemoglobin, PGA2, PGD2, PGE2 and PGF2α was studied in vitro using the canine basilar artery. PGI2 in concentration of 10-6 M caused vasodilation ranging between 20 to 70% of the basal contraction developed by each agonist. Thus it was revealed that PGI2 caused a significant dilation of the artery which had been constricted by any of the above agents. Since the progressive diminution in PGI2 synthesis in experimental SAH has been previously demonstrated, the result of the present study indicates a possible benefit of the us2 of PGI2 as well as the need for preservation of PGI2 synthesis in any pharmacological treatment of vasospasm.
