THE RETURN OF GAGE,PHINEAS - CLUES ABOUT THE BRAIN FROM THE SKULL OF A FAMOUS PATIENT
THE RETURN OF GAGE,PHINEAS - CLUES ABOUT THE BRAIN FROM THE SKULL OF A FAMOUS PATIENT
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DOI：
10.1126/science.8178168
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发表时间：
1994-05-20
期刊：
影响因子：
56.9
通讯作者：
DAMASIO, AR
中科院分区：
文献类型：
--
作者：
DAMASIO, H;GRABOWSKI, T;DAMASIO, AR
1861 年，里程碑式的病人菲尼亚斯·盖奇去世时，没有进行尸检，但他的头骨后来被找到。据推测，导致他的案例出名的深刻性格变化的脑部病变涉及左额叶区域，但人们对其他区域的参与以及病变在广阔的额叶区域内的确切位置提出了疑问。盖奇头骨的测量和现代神经影像技术被用来重建事故并确定病变的可能位置。盖奇的现代同行证实，这种损伤涉及左右前额皮质，导致理性决策和情感处理出现缺陷。
When the landmark patient Phineas Gage died in 1861, no autopsy was performed, but his skull was later recovered. The brain lesion that caused the profound personality changes for which his case became famous has been presumed to have involved the left frontal region, but questions have been raised about the involvement of other regions and about the exact placement of the lesion within the vast frontal territory. Measurements from Gage's skull and modern neuroimaging techniques were used to reconstitute the accident and determine the probable location of the lesion. The damage involved both left and right prefrontal cortices in a pattern that, as confirmed by Gage's modern counterparts, causes a defect in rational decision making and the processing of emotion.