Continuous positive airway pressure for central sleep apnea and heart failure
Continuous positive airway pressure for central sleep apnea and heart failure
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DOI：
10.1056/nejmoa051001
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发表时间：
2005-11-10
影响因子：
158.5
通讯作者：
Floras, JS
中科院分区：
文献类型：
--
作者：
Bradley, TD;Logan, AG;Floras, JS
背景技术背景：加拿大持续气道正压通气治疗中枢性睡眠呼吸暂停和心力衰竭患者试验验证了持续气道正压通气（CPAP）可提高中枢性睡眠呼吸暂停和心力衰竭患者非心脏移植存活率的假设。（平均年龄63 ± 10岁;射血分数24.5 ± 7.7%）和中枢性睡眠呼吸暂停（每小时睡眠呼吸暂停和低通气发作次数40 ± 16次）患者被随机分配接受CPAP治疗（128例）或不接受CPAP治疗（130例），平均随访2年。随访期间，进行睡眠研究，并测量射血分数、运动能力、生活质量和神经激素。结果：随机化三个月后，与对照组相比，CPAP组呼吸暂停和呼吸不足发作频率的降低幅度更大（每小时-21+/-16 vs.-2+/-18，P
BACKGROUND: The Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure trial tested the hypothesis that continuous positive airway pressure (CPAP) would improve the survival rate without heart transplantation of patients who have central sleep apnea and heart failure.METHODS: After medical therapy was optimized, 258 patients who had heart failure (mean age [+/-SD], 63+/-10 years; ejection fraction, 24.5+/-7.7 percent) and central sleep apnea (number of episodes of apnea and hypopnea per hour of sleep, 40+/-16) were randomly assigned to receive CPAP (128 patients) or no CPAP (130 patients) and were followed for a mean of two years. During follow-up, sleep studies were conducted and measurements of the ejection fraction, exercise capacity, quality of life, and neurohormones were obtained.RESULTS: Three months after undergoing randomization, the CPAP group, as compared with the control group, had greater reductions in the frequency of episodes of apnea and hypopnea (-21+/-16 vs. -2+/-18 per hour, P