The role of the glucocorticoid receptor in inflammation and immunity
The role of the glucocorticoid receptor in inflammation and immunity
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DOI：
10.1016/j.jsbmb.2010.03.058
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发表时间：
2010-05-31
影响因子：
4.1
通讯作者：
Tuckermann, Jan
中科院分区：
文献类型：
--
作者：
Baschant, Ulrike;Tuckermann, Jan
糖皮质激素是一种强大的免疫抑制剂，对免疫细胞具有诱导凋亡、改变分化命运、抑制细胞因子释放、抑制迁移等多种作用。糖皮质激素受体(GR)不同的分子机制导致不同的抗炎作用。最近，利用条件基因敲除和功能选择性小鼠研究了炎症模型，揭示了内源性和治疗性GC作用的关键细胞类型和分子机制。在这里，我们回顾了GCs对主要免疫细胞、树突状细胞、髓系细胞以及B和T淋巴细胞的多种作用，并对条件GR基因敲除小鼠的研究进行了总结。(C)2010爱思唯尔有限公司。保留所有权利。
Glucocorticoids are potent immunosuppressive agents with complex actions on immune cells evoking the following effects: inducing apoptosis, changing differentiation fate, inhibition of cytokine release, inhibition of migration and other features. Distinct molecular mechanisms of the glucocorticoid receptor (GR) contribute to different anti-inflammatory effects. Recently inflammatory models have been investigated using conditional knockout and function selective mice shedding light on critical cell types and molecular mechanisms of endogenous and therapeutic GC actions. Here we review the multiple effects of GCs on major immune cells, dendritic cells, myeloid cells and B- and T-lymphocytes and give a summary of studies using conditional GR knockout mice. (C) 2010 Elsevier Ltd. All rights reserved.