Regulation of C-elegans longevity by specific gustatory and olfactory neurons
Regulation of C-elegans longevity by specific gustatory and olfactory neurons
复制标题
DOI：
10.1016/s0896-6273(03)00816-x
复制
发表时间：
2004-01-08
期刊：
影响因子：
16.2
通讯作者：
Kenyon, C
中科院分区：
文献类型：
--
作者：
Alcedo, J;Kenyon, C
C. elegans是通过抑制感觉神经元功能的突变而扩展的。在这项研究中，我们发现感觉神经元的特定子集影响寿命。我们发现，某些味觉神经元抑制寿命，而其他促进寿命，最有可能通过影响胰岛素/IGF-1信号。嗅觉神经元也影响寿命，它们在涉及生殖系统的独特途径中起作用。此外，我们发现，一个假定的化学感觉G蛋白偶联受体，在这些感觉神经元中的一些表达抑制寿命。我们的研究结果表明，C。elegans是由环境的线索，这些线索是感知和整合在一个复杂的和复杂的方式由特定的化学感觉神经元。
The life span of C. elegans is extended by mutations that inhibit the function of sensory neurons. In this study, we show that specific subsets of sensory neurons influence longevity. We find that certain gustatory neurons inhibit longevity, whereas others promote longevity, most likely by influencing insulin/IGF-1 signaling. Olfactory neurons also influence life span, and they act in a distinct pathway that involves the reproductive system. In addition, we find that a putative chemosensory G protein-coupled receptor that is expressed in some of these sensory neurons inhibits longevity. Together our findings imply that the life span of C. elegans is regulated by environmental cues and that these cues are perceived and integrated in a complex and sophisticated fashion by specific chemosensory neurons.