IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection.
IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection.
复制标题
IL-21对于在急性细胞内感染期间诱导KLRG1+效应CD8 T细胞很重要。
DOI：
10.4049/jimmunol.1501258
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Khan IA
中科院分区：
文献类型：
--
作者：
Moretto MM;Khan IA
Microsporidia, a latent opportunistic infection associated with mild inflammation, is characterized by a strong CD8 T cell response, which has been shown to be CD4 T cell dependent. In this manuscript, we demonstrate for the first time that CD4 help is provided via IL-21 production, a common gamma chain cytokine closely related to IL-2. The peak of IL-21 expression, observed during the acute infection, is associated with an elevated IL-21+ CD4 T subset and these cells bear a phenotypic resemblance to T follicular helper cells. We observed that, during per-oral microsporidial infection, IL-21 was critical for the generation of an optimal effector CD8 T cell immunity. Sharply decreased effector KLRG1+ CD8 response was observed in IL-21R knockout mice and while these cells exhibited reduced functional properties they retained the ability to proliferate. The role of IL-21 in the generation of CD8 effectors was cell intrinsic, as stronger defects were observed in the IL-21 deficient compartment from the bone marrow chimeric mice (IL-21R KO/wild type). These findings are different from those reported for viral infections where IL-21 has been primarily associated with the generation and maintenance of CD8 memory response. To the best of our knowledge, this report demonstrates a critical role for IL-21 in the generation of a primary effector CD8 T cells response to an infectious disease model.
