Uterine Leiomyosarcoma Associated With Leiomyoma With Bizarre Nuclei: Histology and Genomic Analysis of 2 Cases.
Uterine Leiomyosarcoma Associated With Leiomyoma With Bizarre Nuclei: Histology and Genomic Analysis of 2 Cases.
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DOI：
10.1097/pgp.0000000000000837
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发表时间：
2022-11-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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奇异核平滑肌瘤（LM BN）是一种罕见的平滑肌瘤的变异与整体良性的临床过程。其组织学特征为局灶性或弥漫性的核小体被普通型平滑肌瘤包围。子宫平滑肌瘤是一组罕见的侵袭性恶性肿瘤，治疗选择有限。LM-BN与平滑肌肉瘤之间的潜在联系在很大程度上是未知的。在这项研究中，我们报告了两例子宫平滑肌肿瘤与LM-BN的典型组织学和分子证据，这与其进展为恶性对应的平滑肌肉瘤。我们总结了这两组病例的详细组织学、形态学和基因组学特征。我们的研究结果表明，平滑肌肉瘤的进展，从预先存在的LM-BN可能是肿瘤的发病途径之一，在子宫平滑肌瘤。
Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with overall benign clinical course. It has histologic features showing focal or diffuse nuclear atypia surrounded by usual type leiomyoma. Uterine leiomyosarcomas are a group of rare and aggressive malignancies with limited treatment options available. The potential association between LM-BN with leiomyosarcoma is largely unknown. In this study, we report two cases of uterine smooth muscle tumor with typical histologic and molecular evidence of LM-BN, which are associated with its progression to the malignant counterpart of leiomyosarcoma. We summarize the detailed histologic, morphologic, and genomic characteristics of these two sets of cases. Our findings suggest that leiomyosarcoma progressing from pre-existing LM-BN can be one of the tumor pathogenesis pathways in uterine leiomyomas.
影响因子：
3.7
作者：
Silveira SM;Villacis RA;Marchi FA;Barros Filho Mde C;Drigo SA;Neto CS;Lopes A;da Cunha IW;Rogatto SR
通讯作者：
Rogatto SR