Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism.
Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism.
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缺血和再灌注引起的大鼠视网膜组织学变化。
DOI：
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发表时间：
1991
影响因子：
4.4
通讯作者：
Pierre Braquer
中科院分区：
文献类型：
--
作者：
Morro E. Szabo;Marie T. Droy;j;Christian Carre;Pierre Braquer
缺血和再灌注诱导的视网膜损伤的组织学改变严重依赖于缺血期的持续时间。将雄性Sprague道利大鼠麻醉，并在包括视网膜中央动脉的地球仪后面放置缝线。由于期望未治疗的眼睛由于再灌注诱导的损伤而显示出巨大的组织学变化（以便存在最大范围以证明药物治疗的任何保护作用），因此初步的一系列研究确立了具有短暂局部缺血的视网膜的时间诱导特征。眼（每组n = 6 - 12）分别经受30、60或90分钟的缺血，随后0.5、1、2、4和24小时的再灌注。30分钟缺血再灌注没有导致任何组织学变化; 60分钟缺血再灌注诱导中度视网膜水肿，再灌注24小时后恢复到缺血前值。90分钟缺血再灌注进一步加重视网膜水肿，增加中性粒细胞的迁移。即使再灌注24小时后，视网膜水肿也没有消失，尽管观察到衰减。在这项研究中，大鼠用超氧化物歧化酶（SOD-PEG，15 × 10（3）U/kg）或EGB 761（100 mg/kg）处理10天（慢性处理）。SOD和EGB 761可显著减轻再灌注诱导的视网膜水肿，并显著防止中性粒细胞浸润。当这些药物在再灌注前给药（"晚期"给药）时，两者对再灌注诱导的损伤也有保护作用。（250字处删节）
Histologic alterations of ischemia- and reperfusion-induced retinal damage are critically dependent on the duration of the period of ischemia. Male Sprague Dawley rats were anesthetized, and a suture was placed behind the globe including the central retinal artery. Because it was desirable that untreated eyes show a great histologic change due to reperfusion-induced damage (in order that maximum scope would exist for demonstration of any protective effect of a drug treatment), a preliminary series of studies established the time-induced characteristics for the retina with transient regional ischemia. Eyes (n = 6-12 in each group) were subjected to 30, 60, or 90 min of ischemia followed by 0.5, 1, 2, 4, and 24 hr of reperfusion, respectively. The 30-min ischemia followed by reperfusion did not result in any histologic changes; 60-min ischemia followed by reperfusion induced a moderate retinal edema which returned to the preischemic value after 24 hr of reperfusion. The 90-min ischemia followed by reperfusion further aggravated retinal edema and increased the migration of neutrophil leukocytes. Even after 24 hr of reperfusion, the retinal edema had not disappeared although an attenuation was observed. In this study, the rats were treated with superoxide dismutase (SOD-PEG, 15 x 10(3) U/kg) or EGB 761 (100 mg/kg) for 10 days (chronic treatment). The SOD and EGB 761 significantly reduced the development of reperfusion-induced retinal edema and significantly prevented the neutrophil leukocyte infiltration. Both also had a protective effect against reperfusion-induced injury when these agents were administered just before reperfusion ("late" administration).(ABSTRACT TRUNCATED AT 250 WORDS)
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锌对离体灌注大鼠心脏再灌注心律失常的影响。
影响因子：
7.4
作者：
Powell,S;Saltman,P;Uretzky,G;Chevion,M
通讯作者：
Chevion,M
影响因子：
20.1
作者：
Kontos,HA
通讯作者：
Kontos,HA
抗坏血酸抑制发炎眼组织中多形核白细胞的活性。
影响因子：
3.4
作者：
Williams,RN;Paterson,CA;Eakins,KE;Bhattacherjee,P
通讯作者：
Bhattacherjee,P
影响因子：
1.6
作者：
Juarez,CP;Tso,MO;vanHeuven,WA;Hayreh,MS;Hayreh,SS
通讯作者：
Hayreh,SS
缺氧、缺血和炎症。
DOI：
--
发表时间：
1986
期刊：
Acta physiologica Scandinavica. Supplementum
影响因子：
--
作者：
Weiss,SJ
通讯作者：
Weiss,SJ