THE NUDE-MOUSE AS AN INVIVO MODEL FOR HUMAN BREAST-CANCER INVASION AND METASTASIS
THE NUDE-MOUSE AS AN INVIVO MODEL FOR HUMAN BREAST-CANCER INVASION AND METASTASIS
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DOI：
10.1007/bf01833265
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发表时间：
1993-01-01
影响因子：
3.8
通讯作者：
SPANGTHOMSEN, M
中科院分区：
文献类型：
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作者：
BRUNNER, N;BOYSEN, B;SPANGTHOMSEN, M
人乳腺癌异种移植物在裸鼠中很少侵袭和转移。因此作为研究乳腺癌扩散机制的模型的用途有限。然而，最近的报告描述的差异，不仅在各种细胞系之间，而且在免疫缺陷小鼠品系之间的人乳腺癌异种移植物的侵袭性和转移能力的研究提供了一个模型。用lacZ基因对人癌细胞进行基因标记被描述为在这样的模型中识别微转移的特异性和高度灵敏的方法。
Human breast cancer xenografts only rarely invade and metastasize in nude mice. and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model.