The relationship between cortical thickness and body mass index differs between women with anorexia nervosa and healthy controls
The relationship between cortical thickness and body mass index differs between women with anorexia nervosa and healthy controls
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DOI：
10.1016/j.pscychresns.2016.01.002
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发表时间：
2016-02-28
影响因子：
2.3
通讯作者：
Soares, Jair C.
中科院分区：
文献类型：
--
作者：
Lavagnino, Luca;Amianto, Federico;Soares, Jair C.
神经性厌食症(AN)是一种严重的精神障碍，其特征是体重极度不足。用结构核磁共振进行的研究发现，几个区域的大脑体积都有所减少，但结果喜忧参半。在其他样本中，皮质厚度与不同BMI范围内的BMI有特定的相关性。在这项研究中，我们应用Freesurfer软件工具包中实施的经过充分验证的程序来调查21名AN患者和18名健康对照样本的皮质厚度，重点关注组内差异以及BMI和皮质厚度之间的关系。在AN患者中，皮质厚度减少，但在多次比较中，组内差异没有得到纠正。AN患者左侧顶上/枕叶皮质和左侧中央后皮质的BMI与皮质厚度的关系与对照组相比有显著差异。这些发现表明，病程不到两年的AN患者的皮质厚度与BMI之间的关系明显不同于对照组，并讨论了可能解释这种关系的生物学机制。(C)2016爱思唯尔爱尔兰有限公司。保留所有权利。
Anorexia nervosa (AN) is a severe psychiatric disorder characterized by extreme underweight. Studies conducted with structural MRI found reductions in brain volumes in several areas, but results are mixed. Cortical thickness has shown in other samples specific correlations with BMI in different BMI ranges. In this study, we applied a well validated procedure implemented in Freesurfer software toolkit to investigate cortical thickness in a sample of 21 patients with AN and 18 healthy controls, focusing on group differences and on the relationship between BMI and cortical thickness. Cortical thickness was reduced in patients with AN, but group differences did not survive correction for multiple comparisons. The relationship between BMI and cortical thickness was significantly different in patients with AN compared to controls in the left superior parietal/occipital cortex and left post central cortex. These findings suggest that the relationship between cortical thickness and BMI in patients with AN with less than two years of illness duration significantly differs from that in controls and possible biological mechanisms that may explain this relationship are discussed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.