Population Genetic Inference From Resequencing Data
Population Genetic Inference From Resequencing Data
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DOI：
10.1534/genetics.107.080630
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发表时间：
2009-01-01
期刊：
影响因子：
3.3
通讯作者：
Marjoram, Paul
中科院分区：
文献类型：
--
作者：
Jiang, Rong;Tavare, Simon;Marjoram, Paul
本文研究了霰弹枪重测序数据的统计建模及其在群体遗传推断中的应用。我们对合成测序技术（如Solexa、454和聚合酶菌落（polony）系统）产生的数据进行建模，这些技术的使用正变得越来越广泛。我们展示了如何使用这些数据来估计进化参数（突变和重组率），尽管这些数据不一定提供完整或对齐的序列信息。我们还提出了我们的方法的两个改进：一个，更健壮。到排序错误和另一个。当没有可用的参考基因组时调用。
This article is concerned with statistical modeling of shotgun resequencing data and the use Of Such data for population genetic inference. We model data produced by sequencing-by-synthesis technologies such as the Solexa, 454, and polymerase colony (polony) systems, whose Use is becoming increasingly widespread. We show how Such data can be used to estimate evolutionarily parameters (Mutation and recombination rates), despite the fact that the data do not necessarily provide complete or aligned sequence information. We also present two refinements of our methods: one that, is more robust. to sequencing errors and another that. call be used when no reference genome is available.