Exosomes: novel biomarkers for clinical diagnosis.
Exosomes: novel biomarkers for clinical diagnosis.
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外泌体：用于临床诊断的新型生物标志物
DOI：
10.1155/2015/657086
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发表时间：
2015
影响因子：
--
通讯作者：
Wang XZ
中科院分区：
文献类型：
--
作者：
Lin J;Li J;Huang B;Liu J;Chen X;Chen XM;Xu YM;Huang LF;Wang XZ
外泌体是30-120 nm内吞膜衍生的囊泡，其参与细胞间通讯以及蛋白质和RNA递送。外泌体含有多种蛋白质、核酸和脂质，并且存在于许多甚至所有体液中。大量文献已经证明，外泌体的分子组分，特别是外泌体蛋白和microRNA（miRNA），作为用于临床诊断的新型生物标志物具有很大的前景。本文综述了近年来外来体生物标志物的研究进展及其在临床诊断中的潜在应用。我们还提供了一个简要概述的形成，功能和分离的外来体。
Exosomes are 30–120 nm endocytic membrane-derived vesicles that participate in cell-to-cell communication and protein and RNA delivery. Exosomes harbor a variety of proteins, nucleic acids, and lipids and are present in many and perhaps all bodily fluids. A significant body of literature has demonstrated that molecular constituents of exosomes, especially exosomal proteins and microRNAs (miRNAs), hold great promise as novel biomarkers for clinical diagnosis. In this minireview, we summarize recent advances in the research of exosomal biomarkers and their potential application in clinical diagnostics. We also provide a brief overview of the formation, function, and isolation of exosomes.