Genomic diversity of Clostridium difficile strains
Genomic diversity of Clostridium difficile strains
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DOI：
10.1016/j.resmic.2015.02.002
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发表时间：
2015-05-01
影响因子：
2.6
通讯作者：
Rupnik, Maja
中科院分区：
文献类型：
--
作者：
Janezic, Sandra;Rupnik, Maja
探索艰难梭菌基因组多样性的方法包括从分子分型方法到使用比较基因组微阵列和全基因组序列比较。艰难梭菌种群结构为克隆性，分布于6个分支，与MLST、STS(多位点序列类型)和PCR核型有很好的相关性。然而，产毒菌株和毒力增强的菌株分布在几个分支中。本文对艰难梭菌基因组多样性的研究进行了综述，重点介绍了艰难梭菌的系统发育、流行病学和某些毒力因子的变异性。(C)2015年巴斯德研究所。爱思唯尔·马森公司出版。版权所有。
Approaches to exploring Clostridium difficile genomic diversity have ranged from molecular typing methods to use of comparative genome microarrays and whole genome sequence comparisons. The C. difficile population structure is clonal and distributed into six clades, which correlate well with MLST STs (multilocus sequence types) and PCR ribotypes. However, toxigenic strains and strains with increased virulence are distributed throughout several clades. Here we summarize studies on C. difficile genomic diversity, with emphasis on phylogenetic aspects, epidemiological aspect and variability of some virulence factors. (C) 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.