TAXOL PRODUCES A PREDOMINANTLY SENSORY NEUROPATHY
TAXOL PRODUCES A PREDOMINANTLY SENSORY NEUROPATHY
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DOI：
10.1212/wnl.39.3.368
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发表时间：
1989-03-01
期刊：
影响因子：
9.9
通讯作者：
SCHAUMBURG, HH
中科院分区：
文献类型：
--
作者：
LIPTON, RB;APFEL, SC;SCHAUMBURG, HH
Taxol, a plant alkaloid with promise as an antineoplastic agent, produced a predominantly sensory neuropathy in 16 of 60 patients treated in two phase I trials. This neuropathy occurred only at taxol doses greater than 200 mg/m2. Symptoms typically started 1 to 3 days following treatment, beginning in the hands and feet simultaneously in most patients. Electrophysiologic data suggests both axonal degeneration and demyelination. This previously undefined neurotoxic neuropathy most likely results from taxol''s unique ability to produce microtubule aggregation in dorsal root ganglion cells, axons, and Schwann cells.
