Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta.
Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta.
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先兆子痫/子痫易感性母体基因与 HLA DR β 之间缺乏密切联系。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
P. Marshall
中科院分区：
文献类型：
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作者：
A. Wilton;D. Cooper;S. Brennecke;S. M. Bishop;P. Marshall
为了测试母体表达的先兆子痫/子痫易感基因与人类基因组6号染色体上的HLA区域紧密连锁的可能性，通过TaqI引物对具有多个这些疾病病例的10个家系的成员进行HLA DR β限制性片段长度多态性分型。数据进行了分析，通过LIPED程序计算lod分数，通过几个程序来检测潜在的异质性的重组分数之间的家系，和受影响的同胞和受影响的家系成员的方法。结果排除了密切联系。如果假定的易感基因位于6号染色体上，它们必须位于至少5厘摩，可能更多，从HLA DR β位点。没有迹象表明在较高的重组分数的连锁被发现。影响先兆子痫易感性的主要母系表达基因不在HLA区域。
To test the possibility that maternally expressed susceptibility genes for pre-eclampsia/eclampsia are closely linked to the HLA region on chromosome 6 of the human genome, members of ten pedigrees with multiple cases of these disorders were typed for HLA DR beta restriction fragment length polymorphisms by means of TaqI digests. The data were analysed by the LIPED program to calculate lod scores, by several programs to detect potential heterogeneity of recombination fraction between pedigrees, and by the affected-sibling and the affected-pedigree-member methods. The results exclude close linkage. If the putative susceptibility genes lie on chromosome 6 they must lie at least 5 centiMorgans, and probably more, from the HLA DR beta loci. No indication of linkage at higher recombination fractions was found. The main maternally expressed genes affecting susceptibility to pre-eclampsia are not in the HLA region.