Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese[S]
Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese[S]
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红细胞多不饱和脂肪酸、循环酰基肉碱和代谢综合征风险：一项中国前瞻性研究
DOI：
10.1194/jlr.p088005
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发表时间：
2019-02-01
影响因子：
6.5
通讯作者：
Lin, Xu
中科院分区：
文献类型：
--
作者：
Ma, Yiwei;Sun, Liang;Lin, Xu
多不饱和脂肪酸对代谢综合征(METS)的影响尚不清楚，特别是在亚洲人中。我们的目的是调查多不饱和脂肪酸与蛋氨酸的预期关联，以及酰肉碱在中国人这些关联中的作用。对1245名年龄在50~70岁的中国男性和女性进行6年随访，用气相色谱-正化学电离联用法和液质联用法分别测定基础红细胞FAs和血浆酰卡尼汀。与极端四分位数相比，总n-6多不饱和脂肪酸和3个22-碳n-6多不饱和脂肪酸显著地与较低的Met风险相关：总n-6多不饱和脂肪酸的相对风险(RR)(95%CI)为0.75(0.57，0.97)，22：2n-6的相对风险(RR)为0.69(0.56，0.85)，22：4n-6的相对风险(RR)为0.76(0.59，0.99)，22：5n-6的相对风险为0.74(0.58，0.94)，18：3n-3和18：3n-6与蛋氨酸风险呈正相关。在网络分析中，主要由长链n-6多不饱和脂肪酸和超长链饱和脂肪酸组成的模块与蛋氨酸事件呈负相关(RR Per SD：0.84；95%CI：0.76，0.92)，并且当短链到中链酰基肉碱(C5-C10)模块得分较低时，该模块与Mets风险的相关性更强(P-交互作用=0.03)。我们的数据表明，总n-6和某些长链n-6多不饱和脂肪酸与心脏代谢性疾病呈负相关，这种相关性可能被某些乙酰基-L-肉碱改变。
The effects of PUFAs on metabolic syndrome (MetS) remain to be characterized, particularly in Asians. We aimed to investigate the prospective associations of PUFAs with MetS and the role of acylcarnitines in these associations in Chinese individuals. Among 1,245 Chinese men and women aged 50-70 years who completed a 6 year follow-up, baseline erythrocyte FAs and plasma acylcarnitines were profiled using gas chromatography coupled with positive chemical ionization and liquid chromatography-tandem mass spectrometry, respectively. Total n-6 PUFAs and three 22-carbon n-6 PUFAs were significantly associated with lower MetS risk comparing extreme quartiles: relative risks (RRs) (95% CIs) were 0.75 (0.57, 0.97) for total n-6 PUFAs, 0.69 (0.56, 0.85) for 22:2n-6, 0.76 (0.59, 0.99) for 22:4n-6, and 0.74 (0.58, 0.94) for 22:5n-6, while 18:3n-3 and 18:3n-6 were positively associated with MetS risk. In a network analysis, a module mostly consisting of long-chain n-6 PUFAs and very-long-chain saturated FAs was inversely associated with incident MetS (RR per SD: 0.84; 95% CI: 0.76, 0.92), and this module was more strongly associated with lower MetS risk when a short- to medium-chain acylcarnitine (C5-C10) module score was lower (P-interaction = 0.03). Our data suggested inverse associations of total n-6 and certain long-chain n-6 PUFAs with cardiometabolic disorders, and this association might be modified by certain acy-l-carnitines.