LOCAL MODULATION OF NEUROFILAMENT PHOSPHORYLATION, AXONAL CALIBER, AND SLOW AXONAL-TRANSPORT BY MYELINATING SCHWANN-CELLS
LOCAL MODULATION OF NEUROFILAMENT PHOSPHORYLATION, AXONAL CALIBER, AND SLOW AXONAL-TRANSPORT BY MYELINATING SCHWANN-CELLS
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DOI：
10.1016/0092-8674(92)90183-d
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发表时间：
1992-02-07
期刊：
影响因子：
64.5
通讯作者：
BRADY, ST
中科院分区：
文献类型：
--
作者：
DEWAEGH, SM;LEE, VMY;BRADY, ST
对Trembler和对照小鼠的研究表明，髓鞘化雪旺细胞对轴突有深远的影响。髓磷脂和轴突之间的广泛接触被认为是结构性的。然而，脱髓鞘降低了神经丝磷酸化，减缓了轴突运输，降低了轴突直径，并显著增加了神经丝密度。在移植物震颤神经节段的对照坐骨神经中，这些变化在空间上受到限制：它们局限于轴突节段，没有正常的髓鞘形成。同一轴突相邻区域的直径、神经丝磷酸化、细胞骨架组织和轴突运输速率正常。髓鞘雪旺细胞和轴突之间的密切细胞间接触调节了作用于神经丝和可能的其他底物的激酶-磷酸酶系统。雪旺细胞的髓鞘形成改变了轴突的功能结构、电学性质和神经元形态。
Studies in Trembler and control mice demonstrated that myelinating Schwann cells exert a profound influence on axons. Extensive contacts between myelin and axons have been considered structural. However, demyelination decreases neurofilament phosphorylation, slow axonal transport, and axonal diameter, as well as significantly increasing neurofilament density. In control sciatic nerves with grafted Trembler nerve segments, these changes were spatially restricted: they were confined to axon segments without normal myelination. Adjacent regions of the same axons had normal diameters, neurofilament phosphorylation, cytoskeletal organization, and axonal transport rates. Close intercellular contacts between myelinating Schwann cells and axons modulate a kinase-phosphatase system acting on neurofilaments and possibly other substrates. Myelination by Schwann cells sculpts the axon-altering functional architecture, electrical properties, and neuronal morphologies.