The Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium: A Transdisciplinary Approach Toward Promoting Bladder Health and Preventing Lower Urinary Tract Symptoms in Women Across the Life Course
The Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium: A Transdisciplinary Approach Toward Promoting Bladder Health and Preventing Lower Urinary Tract Symptoms in Women Across the Life Course
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DOI：
10.1089/jwh.2017.6566
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发表时间：
2018-03-01
影响因子：
3.5
通讯作者：
Simons-Morton, Denise
中科院分区：
文献类型：
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作者：
Harlow, Bernard L.;Bavendam, Tamara G.;Simons-Morton, Denise
下尿路症状（LUTS）在女性中非常普遍，随着人口老龄化，预计会给个人和社会带来越来越大的负担。与LUTS相关的研究主要集中在潜在的病理学，疾病机制或治疗LUTS女性的疗效。虽然这项研究对于帮助减少或改善LUTS状况至关重要，但它对预防LUTS的发生几乎没有作用。健康促进和预防需要扩大科学研究，超越研究疾病机制和治疗的传统范式，建立证据基础，以支持膀胱健康促进的建议，进而预防LUTS。国家糖尿病、消化和肾脏疾病研究所（NIDDK）将预防的概念作为妇女泌尿学研究的重要优先事项，作为支持下尿路症状预防（PLUS）研究联盟成立的前奏。在这篇文章中，我们向科学界介绍了PLUS研究联盟;分享了该联盟运作的创新范式;并描述了其独特的研究使命：确定促进整个生命过程中膀胱健康的因素，并预防女孩和妇女发生LUTS。
Lower urinary tract symptoms (LUTS) are highly prevalent in women, and are expected to impose a growing burden to individuals and society as the population ages. The predominance of research related to LUTS has focused on underlying pathology, disease mechanisms, or the efficacy of treatments for women with LUTS. Although this research has been vital for helping to reduce or ameliorate LUTS conditions, it has done little to prevent the onset of LUTS. Health promotion and prevention require an expansion of scientific inquiry beyond the traditional paradigm of studying disease mechanisms and treatment to the creation of an evidence base to support recommendations for bladder health promotion and, in turn, prevention of LUTS. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) introduced the concept of prevention as an important priority for women's urologic research as a prelude to supporting the formation of the Prevention of Lower Urinary Tract Symptoms (PLUS) research consortium. In this article, we introduce the PLUS research consortium to the scientific community; share the innovative paradigms by which the consortium operates; and describe its unique research mission: to identify factors that promote bladder health across the life course and prevent the onset of LUTS in girls and women.