Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes Patients.
Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes Patients.
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DOI：
10.1900/rds.2014.11.258
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发表时间：
2014-09-01
期刊：
影响因子：
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通讯作者：
Abbasi, Behnoud
中科院分区：
文献类型：
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作者：
Azimi, Paria;Ghiasvand, Reza;Abbasi, Behnoud
2型糖尿病（T2D）可能是由氧化应激、炎症和高血糖引起的。据报道，几种草药中的植物化学物质可以有效地改善糖尿病和改善糖尿病并发症。本研究的目的是确定肉桂，豆蔻，甘草，生姜作为辅助治疗2型糖尿病的效果。方法：这是一项随机对照的临床试验，包括204例2型糖尿病患者。参与者被随机分配到四个干预组，接受3杯红茶和3克豆蔻，肉桂，生姜或1克甘草，以及一个对照组，只喝3杯茶，没有任何草药，持续8周。炎症，氧化应激，空腹血糖，血脂和人体测量指标的标志物进行了评估，在基线和8周后的intervention.RESULTS：8周的干预后，肉桂，豆蔻，生姜和甘草消费量对总胆固醇，低密度脂蛋白和高密度脂蛋白水平有显着影响（p < 0.05）与对照组相比。然而，草药产品对血糖控制，人体测量，炎症和氧化应激的措施没有显着影响。仅在组内比较中，肉桂摄入量显著降低空腹血糖（FBS）。结论：草药检查对胆固醇有显着的有益影响，但对血糖控制，氧化应激和炎症的措施没有影响。基于文献中报道的相互矛盾的结果，草药对糖尿病患者的影响应进行进一步的详细调查。
OBJECTIVES: Type 2 diabetes (T2D) may be caused by elevated oxidative stress, inflammation, and hyperglycemia. The phytochemicals in several herbal medicines are reported to effectively improve diabetes and to ameliorate diabetic complications. The aim of the present study was to determine the effects of cinnamon, cardamom, saffron, and ginger as supplementary remedies in T2D.METHODS: This randomized controlled, clinical trial included 204 T2D patients. The participants were randomly assigned to four intervention groups receiving 3 glasses of black tea and either 3 g cardamom, or cinnamon, or ginger, or 1 g saffron and one control group which consumed only 3 tea glasses without any herbal medicine for 8 weeks. Markers of inflammation, oxidative stress, fasting blood sugar, lipid profile, and anthropometric measures were evaluated at baseline and after 8 weeks of intervention.RESULTS: After 8 weeks of intervention, cinnamon, cardamom, ginger, and saffron consumption had significant effects on total cholesterol, LDL, and HDL levels (p < 0.05) compared with controls. However, the herbal products did not have significant effects on measures of glycemic control, anthropometry, inflammation, and oxidative stress. In within-group comparisons only, cinnamon intake significantly decreased fasting blood sugar (FBS).CONCLUSIONS: The herbal remedies examined had significantly beneficial effects on cholesterol, but not on measures of glycemic control, oxidative stress, and inflammation. Based on the contradictory results reported in the literature, the effects of herbal medicine in diabetic patients should undergo further detailed investigation.