Pregnancy in women with pulmonary hypertension.
Pregnancy in women with pulmonary hypertension.
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DOI：
10.1007/s12471-011-0219-9
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Hoendermis ES
中科院分区：
文献类型：
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作者：
Pieper PG;Hoendermis ES
患有肺动脉高压的妇女在怀孕期间有很高的发病和死亡风险。无法增加心输出量导致心力衰竭，而高凝状态和全身血管阻力降低会带来进一步的风险。没有证据表明肺动脉高压的新的先进疗法可以降低风险，尽管已经报道了一些有希望的结果。然而，妊娠仍应视为肺动脉高压妇女的禁忌。当妊娠发生而终止妊娠被拒绝时，妊娠和分娩应由具有肺动脉高压和高危妊娠管理经验的多学科服务机构管理。
Women with pulmonary hypertension have a high risk of morbidity and mortality during pregnancy. The inability to increase cardiac output leads to heart failure while further risks are introduced with hypercoagulability and decrease in systemic vascular resistance. There is no proof that new advanced therapies for pulmonary hypertension decrease the risk, though some promising results have been reported. However, pregnancy should still be regarded as contraindicated in women with pulmonary hypertension. When pregnancy occurs and termination is declined, pregnancy and delivery should be managed by multidisciplinary services with experience in the management of both pulmonary hypertension and high-risk pregnancies.