Is global elimination of HCV realistic?
Is global elimination of HCV realistic?
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DOI：
10.1111/liv.13668
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发表时间：
2018-02-01
影响因子：
6.7
通讯作者：
Craxi, Antonio
中科院分区：
文献类型：
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作者：
Calvaruso, Vincenza;Petta, Salvatore;Craxi, Antonio
通过新型抗病毒药物的出现，消除丙型肝炎病毒 (HCV) 成为可能，这些药物现在可以用于所有 HCV 感染患者，甚至是失代偿性肝硬化患者。世界卫生组织（WHO）的目标是到2030年将慢性肝炎感染发病率从目前的6-1000万例减少到90万例，年死亡人数从140万例减少到50万例以下。实现这些目标需要全面落实 HCV 感染的流行病学知识、筛查和检测实践以及将 HCV 患者与护理联系起来的策略。本综述将重点关注 HCV 流行病学的当前知识状况以及如何提高患者认识并减少治疗障碍。此外，我们将讨论 HCV 清除对控制 HCV 相关结果的作用。
The elimination of hepatitis C virus (HCV) has been made possible through the availability of new antiviral drugs which may now be administered to all patients with HCV infection, even those with decompensated cirrhosis. The goal of the World Health Organization (WHO) is to reduce the incidence of chronic hepatitis infection from the current 6-10 million to 0.9 million cases of chronic infections by 2030, and annual deaths from 1.4 million to fewer than 0.5 million. Achieving these targets will require full implementation of epidemiological knowledge of HCV infection, screening and testing practices and strategies to link HCV patients to care. This review will focus on the current state of knowledge in the epidemiology of HCV and what can be done to increase patient awareness and reduce the barriers to treatment. Furthermore, we will discuss the role of HCV clearance on the control of HCV-related outcomes.