Immobilized halogenophenylcarbamate derivatives of cellulose as novel stationary phases for enantioselective drug analysis
Immobilized halogenophenylcarbamate derivatives of cellulose as novel stationary phases for enantioselective drug analysis
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DOI：
10.1016/s0731-7085(01)00568-4
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发表时间：
2002-01-15
影响因子：
3.4
通讯作者：
Huynh, D
中科院分区：
文献类型：
--
作者：
Francotte, E;Huynh, D
制备了三种不同的纤维素卤代苯基氨基甲酸酯衍生物，并将其涂敷在硅胶上。涂层材料已被固定化，其作为手性固定相（CSP）的手性识别能力进行了评价与一组参考外消旋体，包括几种药物，如氯甲西泮，谷乙酰亚胺，华法林，使用各种移动的相混合物。新的阶段被发现表现出独特的对映体选择性的性能相比，更成熟的多糖为基础的CSP。所有外消旋体的良好的分辨率可以成功地实现至少一个固定化的CSP。此外，已经指出，选择性可随着移动的相的组成而显著变化。(C)2002 Elsevier Science B.V.保留所有权利。
Three different halogeno-phenylcarbamate derivatives of cellulose have been prepared and coated on silica gel. The coated materials have been immobilized and their chiral recognition ability as chiral stationary phase (CSP) has been evaluated with a set of reference racemates, including several drugs such as lormetazepam, glutethimide, and warfarin, using various mobile phase mixtures. The novel phases were found to exhibit unique enantioselective properties compared with more established polysaccharide-based CSPs. A good resolution of all racemates could be successfully achieved on at least one of the immobilized CSPs. Moreover, it has been pointed out that selectivity may considerably vary with the composition of the mobile phase. (C) 2002 Elsevier Science B.V. All rights reserved.