Phase and amplitude correlations in resting-state activity in human stereotactical EEG recordings
Phase and amplitude correlations in resting-state activity in human stereotactical EEG recordings
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DOI：
10.1016/j.neuroimage.2015.02.031
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发表时间：
2015-05-15
期刊：
影响因子：
5.7
通讯作者：
Palva, J. Matias
中科院分区：
文献类型：
--
作者：
Arnulfo, Gabriele;Hirvonen, Jonni;Palva, J. Matias
神经元振荡的区域间相互作用可能是协调解剖分布的神经元处理的关键机制。在人类中，有创立体脑电描记术（SEEG）由于其出色的空间和时间分辨率而成为电生理记录的参考方法。因此，它也可以被认为是映射神经元区域间相互作用的最佳方法。然而，SEEG数据的常见双极（BP）参考可能混淆来自不同来源的信号并抑制真正的神经元相互作用，而替代单极（MP）参考产生被体积传导污染的数据。我们在这里提出了一种新的参考方案SEEG数据中的电极在灰质引用最接近的白质（CW）电极。使用22个受试者队列和这三个参考方案，我们观察到区域间相位和振幅相关性随距离和频率衰减，但在10 cm的距离内保持显著和稳定。此外，我们发现，深层和浅层皮层表现出不同的频谱配置文件的振荡功率以及不同的模式，区域间的相位和振幅的相互作用。这些影响在MP和CW中定性相似，但与BP参考失真。重要的是，CW不受MP固有的明显大规模体积传导的影响。因此，我们在这里证明，与CW参考，可以利用SEEG的上级解剖精度，以产生准确的量化和定性的新见解的相位和幅度的相互作用，在人脑活动。(C)2015 Elsevier Inc. All rights reserved.
Inter-areal interactions of neuronal oscillations may be a key mechanism in the coordination of anatomically distributed neuronal processing. In humans, invasive stereo-electroencephalography (SEEG) is emerging as a reference method for electrophysiological recordings because of its excellent spatial and temporal resolution. It could thus be also considered an optimal method for mapping neuronal inter-areal interactions. However, the common bipolar (BP) referencing of SEEG data may both confuse signals from distinct sources and suppress true neuronal interactions whereas the alternative monopolar (MP) reference yields data contaminated by volume conduction. We advance here a novel referencing scheme for SEEG data where electrodes in grey matter are referenced to closest white-matter (CW) electrodes. Using a 22 subject cohort and these three referencing schemes, we observed that both inter-areal phase and amplitude correlations decayed as function of distance and frequency but remained significant and stable across distances up to 10 cm. Furthermore, we found that deep and superficial cortical laminae exhibit distinct spectral profiles of oscillation power as well as distinct patterns of inter-areal phase and amplitude interactions. These effects were qualitatively similar in MP and CW but distorted with BP referencing. Importantly CW was not influenced by the apparent large-scale volume conduction inherent to MP. We thus demonstrate here that with CW referencing, the superior anatomical accuracy of SEEG can be leveraged to yield accurate quantification and qualitatively novel insight into phase and amplitude interactions in human brain activity. (C) 2015 Elsevier Inc. All rights reserved.